Placental Steroid Dehydrogenases: Assessment with a Nonhuman Primate in Situ Placental Perfusion Model
The oxidoreductase activity of 17β-hydroxysteroid dehydrogenase (17β-HSD) has been demonstrated in human placenta and catalyzes the interconversion of estradiol-17β (E2) and estrone (E1) (Langer and Engel, 1958; Jarabak and Sack, 1969; Strickler and Tobias, 1982). Preimplantation rat and mouse embryos have also been reported to possess 17β-HSD activity (Wu and Lin, 1982; Wu and Matsumoto, 1985). It has been postulated that 17β-HSD is responsible for the conversion of the potent estrogen, E2, to the less potent E1 in later-term non-human primate pregnancy (Slikker et al., 1982a) and regulates the ratio of E2 and E1 throughout the preimplantation period in the rodent (Wu and Matsumoto, 1985).
Unable to display preview. Download preview PDF.
- Althaus, Z.R., Bailey, J.R., Leakey, J.E.A., and Slikker, W., Jr. (1986) Transplacental metabolism of dexamethasone and cortisol in the late gestational age monkey (Macaca mulatta). Develop. Pharmacol. Ther.,in press.Google Scholar
- Bernal, A.L., Flint, A.P.F., Anderson, A.B.M., and Turnbull, A.C. (1980) 1113hydroxysteroid dehydrogenase activity (E.C. 184.108.40.206) in human placenta and decidua. J. Steroid Biochem. 13, 1081–1087.Google Scholar
- Hill, D.E., Slikker, W., Jr., Goad, P.T., Bailey, J.R., Szisazk, T.J., and Hendrickx, A.G. (1983) Maternal, fetal, and neonatal elimination of ethanol in nonhuman primates. Develop. Pharmacol. Ther. 6, 259–268.Google Scholar
- Slikker, W., Jr., Althaus, Z.R., Rowland, J.M., Hendrickx, A.G., and Hill, D.E. (1984a) Comparison of the metabolism of cortisol and triamcinolone acetonide in the early, mid and late gestation age rhesus monkey (Macaca mulatta). Develop. Pharmacol. Ther. 7, 319–333.Google Scholar
- Stolte, L.A.M. (1975) Pregnancy in the rhesus monkey. In: The Rhesus Monkey, vol. II, (ed.), G.W. Bourne, pp. 171–230.Google Scholar
- Strickler, R.C. and Tobias, B. (1982) 20a-hydroxysteroid dehydrogenase and 17ßestradiol dehydrogenase localize in cytosol of human term placenta. Am. J. Physiol. 242(3), 178–183.Google Scholar