Advertisement

Characterization of Magnetic Resonance Parameters in the Pregnant Uterus

  • Peter J. Thomford
  • Janet Jordan
  • Teresita Angtuaco
  • H. Howard Cockrill
  • Donald R. Mattison
Chapter
Part of the Trophoblast Research book series (TR)

Abstract

Although not widely appreciated, nuclear magnetic resonance (NMR) spectroscopy has been used as a research tool in obstetrics and gynecology for many years. Odeblad and colleagues have used NMR to characterize the structure of water in human vaginal cells (Odeblad, 1959), human milk (Odeblad and Westin, 1958), myometrium (Odeblad and Ingelman-Sundberg, 1965) and cervical mucus (Odeblad and Bryhn, 1957). Recently, with the growing availability of magnetic resonance imaging (MRI) units there has been an interest in exploring the technique in obstetrics (Smith et al., 1983; Johnson et al., 1984) and gynecology (Thickman et al., 1984). Indeed, a recent report suggests that MRI may be useful in prenatal evaluation of intrauterine growth retardation — by virtue of its ability to quantitate subcutaneous fat (Stark et al., 1985).

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alger, J.R. and Shulman, R.G. (1984) Metabolic application of high-resolution 13C nuclear magnetic resonance spectroscopy. Br. Med. Bull. 40, 160–164.PubMedGoogle Scholar
  2. Beall, P.T., Amtey, S.R., and Kasturi, S.R. (1984) NMR Data Handbook for Biomedical Applications, Pergamon Press, New York, pp. 101–153.Google Scholar
  3. Behar, K.L., DenHollander, J.A., Stromshi, M.E., Ogino, T., Shulman, R.G., Petroff, O.A.C., and Prichard, J.W. (1983) High resolution 1H nuclear magnetic resonance study of cerebral hypoxia in vivo. Proc. Natl. Acad. Sci. USA 80, 4945–4948.PubMedCrossRefGoogle Scholar
  4. Bene, G.J., Borcard, B., Graf, V., Hiltbrand, E., Magnin, P., and Noach, F. (1982) Proton NMR-relaxation dispersion in meconium solutions and healthy amniotic fluid: possible applications to medical diagnosis. Z. Naturforsch 37, 394–398.Google Scholar
  5. Bock, J.L. (1985) Recent developments in biochemical nuclear magnetic resonance spectroscopy. Methods Bioch. Analy. 31, 259–315.CrossRefGoogle Scholar
  6. Borcard, B., Hiltbrand, E., Magnin, P., Rone, G.J., Briguet, A., Duplan, J.C., Delman, J., Guibaud, S., Bonnet, M., Dumont, M., and Fara, J.F. (1982) Estimating meconium (fetal feces) concentration in human amniotic fluid by nuclear magnetic resonance. Physiol. Chem. Phy. 14, 189–192.Google Scholar
  7. Cady, E.B., Costello, A.M., Dawson, M.J., Delpy, D.T., Hope, P.L., Reynolds, E.O.R., Tofts, P.S., and Wilkie, D.R. (1983) Non-invasive investigation of cerebral metabolism in newborn infants by phosphorous nuclear magnetic resonance spectroscopy. Lancet 1, 1059–1062.PubMedCrossRefGoogle Scholar
  8. Cohen, J.S., Knop, R.H., Navon, G., and Foxall, D. (1983) Nuclear magnetic resonance in biology and medicine. Life Chem. Rep. 1, 281–457.Google Scholar
  9. Damadian, R. (1981) NMR in Medicine, Springer-Verlag, New York.CrossRefGoogle Scholar
  10. Foster, M.A. (1984) Magnetic Resonance in Biology and Medicine, Pergamon Press, New York.Google Scholar
  11. Fukushima, E. and Roeder, S.B.W. (1981) Experimental Pulse NMR. A Nuts and Bolts Approach. Addison-Wesley, Reading, MA.Google Scholar
  12. Gadian, D.G. (1982) Nuclear Magnetic Resonance and its Applications to Living Systems. Oxford University Press, New York.Google Scholar
  13. Gore, J.C. and Smith, F.W. (1985) Contrast Agents. Magnetic Resonance Imaging 3, 1–97.CrossRefGoogle Scholar
  14. Johnson, I.R., Symond, E.M., Kean, D.M., Worthington, B.S., Broughton, Pipkin, F., Hawkes, R.C., and Gyngell, M. (1984) Imaging the pregnant human uterus with nuclear magnetic resonance. Am. J. Obstet. Gynecol. 148, 1136–1139.Google Scholar
  15. Kay, H.H. and Mattison, D.R. (1986) Magnetic Resonance Imaging in Nonhuman Primates. In: Animals in Perinatal Research,(ed.), P.W. Nathanielsz, in press.Google Scholar
  16. Maudsley, A.A. and Hilal, S.K. (1984) Biological aspects of sodium-23 imaging. Br. Med. Bull. 40, 165–166.PubMedGoogle Scholar
  17. Meis, P.J., Hall, M., Marshall, J.R., and Hobel, C.J. (1978) Meconium passage: a new classification for risk assessment during labor. Am. J. Obstet. Gynecol. 131, 509–513.PubMedGoogle Scholar
  18. Mitchell, M.R., Conturo, T.E., Gruber, T.J., and Jones, J.P. (1984) Two computer models for selection of optimal magnetic resonance imaging (MRI) pulse sequence timing. Invest. Radiol. 19, 350–360.PubMedCrossRefGoogle Scholar
  19. Moore, W.S. (1984) Basic physics and relaxation mechanisms. Br. Med. Bull. 40, 120–125PubMedGoogle Scholar
  20. Odeblad, E. (1959) Studies on vaginal contents and cells with proton magnetic resonance. Ann. NY Acad. Sci. 3, 189–206.Google Scholar
  21. Odeblad, E. and Bryhn, U. (1957) Proton magnetic resonance of human cervical mucus during the menstrual cycle. Acta Radiol. 47, 315–320.PubMedCrossRefGoogle Scholar
  22. Odeblad, E. and Ingelman-Sundberg, A. (1965) Proton magnetic resonance studies on the structure of water in the myometrium. Acta Obstet. Gynec. Scand. 44, 117–120PubMedCrossRefGoogle Scholar
  23. Odeblad, E. and Westin, B. (1958) Proton magnetic resonance of human milk. Acta Radiologica 49, 389–392.PubMedCrossRefGoogle Scholar
  24. Partain, C.L., James, A.E., Rollo, F.D., and Price, R.R. (eds.) (1983) Nuclear Magnetic Resonance (NMR) Imaging, Saunders, Philadelphia.Google Scholar
  25. Pople, J.A., Schneider, W.G., and Bernstein, H.J. (1959) High Resolution Nuclear Magnetic Resonance, McGraw-Hill, New York.Google Scholar
  26. Prichard, J.W., Alger, J.R., Behar, K.L., Petroff, O.A.C., and Shulman, R.G. (1983) Cerebral metabolic studies in vivo by 3113 NMR. Proc. Natl. Acad. Sci. USA 80, 2748–2751.PubMedCrossRefGoogle Scholar
  27. Radda, G.K., Bore, P.J., and Rajagopalan, B. (1984) Clinical aspects of 3113 NMR spectroscopy. Br. Med. Bull. 40, 155–159.PubMedGoogle Scholar
  28. Smith, F.W., Adams, A., and Phillips, W.P. (1983) NMR imaging in pregnancy. Lancet 1, 61–62.PubMedCrossRefGoogle Scholar
  29. Stark, D.D., Hricak, H., and Paver, J.T. (1985) Intrauterine growth retardation: evaluation by magnetic resonance. Radiol. 155, 425–427.Google Scholar
  30. Steiner, R.E. and Radda, G.K. (1984) Nuclear magnetic resonance and its clinical applications. Br. Med. Bull. 40, 113–206.Google Scholar
  31. Thickman, D., Kressel, H., Gussman, D., Axel, L., and Hogan, M. (1984) Nuclear magnetic resonance imaging in gynecology. Am. J. Obstet. Gynecol. 149, 835–840.PubMedCrossRefGoogle Scholar
  32. Weisman, I.D., Bennett, L.H., Maxwell, L.R., and Henson, D.E. (1981) Cancer detection by NMR in the living animal. In: NMR in Medicine, (ed.), R. Damadian, Springer-Verlag, New York, pp. 17–37.CrossRefGoogle Scholar
  33. Wolf, G.L. (1984) Contrast enhancement in biomedical NMR: A symposium. Physiol. Chem. Phys. Med. NMR 16, 89–172.Google Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Peter J. Thomford
    • 1
    • 5
  • Janet Jordan
    • 1
  • Teresita Angtuaco
    • 2
  • H. Howard Cockrill
    • 3
  • Donald R. Mattison
    • 1
    • 4
    • 5
  1. 1.Departments of Obstetrics and GynecologyUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Departments of Obstetrics and RadiologyUniversity of Arkansas for Medical SciencesLittle RockUSA
  3. 3.Radiological AssociatesLittle RockUSA
  4. 4.Departments of Obstetrics and PharmacologyUniversity of Arkansas for Medical SciencesLittle RockUSA
  5. 5.The National Center for Toxicological ResearchJeffersonUSA

Personalised recommendations