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The Placenta as a Model for Toxicity Screening of New Molecules

  • Rebecca Beaconsfield
  • Bojana Cemerikic
  • Olga Genbacev
  • Vojin Sulovic
Chapter
Part of the Trophoblast Research book series (TR)

Abstract

Our in vitro model of placental tissue explants is designed to assess the direct acute effect of drugs on trophoblast cell metabolism (Genbacev et al., 1982). The possible clinical implications of the information obtained are indirect, but it could be inferred that alterations in trophoblast cell metabolism affects in turn fetal well being. Our purpose was to evaluate, using the described experimental model, the direct effect of two groups of drugs that are believed to have adverse effects on fetal growth: negative /morphine and morphine-like substances and nicotine/ and positive /beta-mimetic drugs. The parameters selected were glucose uptake, lactate production, 14C-Leucine uptake and incorporation into total soluble proteins, placental hormone release and intracellular cAMP content (Genbacev et al., 1982).

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Rebecca Beaconsfield
    • 1
  • Bojana Cemerikic
    • 1
  • Olga Genbacev
    • 1
  • Vojin Sulovic
    • 1
  1. 1.INEP Department of EndocrinologyImmunology and NutritionZemunYugoslavia

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