Advertisement

Studies of C1q Deposits in the Human Placenta Using Monoclonal Antibodies to Human Extra-Embryonic Tissues

  • Bae-Li Hsi
  • Chang-Jing G. Yeh
Chapter
Part of the Trophoblast Research book series (TR)

Abstract

The presence of the first complement component around some fetal stem vessels in the chorionic villous stroma of term human placentae was first reported by Faulk and Johnson (1977) using the antiserum to Clq. This finding was later extended to the immature placenta (Johnson and Faulk, 1978). Sinha et al. (1984) showed that more anti-Clq positive fetal blood vessels and fibrinoid structures could be seen in the placentae from patients with pre-eclampsia. Although, the pathogenesis of this type of fetal stem vessels was unclear, it has been suggested that they may be mediated by immunological mechanisms (Sinha et al., 1984). Morphologically, two types of lesions of fetal stem vessels have been described, namely, fibromuscular sclerosis and obliterative endarteritis (Fox, 1978). The fibromuscular sclerosis of fetal stem arteries was often associated with villous infarction and the villi which were embedded in the fibrinous plaque. The cause of this lesion was suggested to be the cessation of fetal blood flow in these blood vessels. On the other hand, the fetal arterial obliterative endarteritis was found more often in the placentae of women with pre-eclampsia, essential hypertension or diabetes melitus. It has been proposed that it was the consequence of hypoxia of the placentae (Fox, 1967a).

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Boyd, J.D. and Hamilton, W.J. (1970) The Human Placenta. London: Heller.Google Scholar
  2. Faulk, W.P. and Johnson, P.M. (1977) Immunological studies of human placentae: identification and distribution of proteins in mature chorionic villi. Clin. Exp. Immunol. 27, 365–375.PubMedCentralPubMedGoogle Scholar
  3. Fox, H. (1967a) Abnormalities of foetal stem arteries in the human placenta. J. Obstet. Gynaecol. Brit. Cwlth. 74, 734–738.CrossRefGoogle Scholar
  4. Fox, H. (1967b) Perivillous fibrin deposition in the human placenta. Am. J. Obstet. Gynecol. 98, 245–251.PubMedGoogle Scholar
  5. Fox, H. (1978) Pathology of the Placenta. London: W.B. Saunders, Co.Google Scholar
  6. Hsi, B.-L. and Yeh, C.-J.G. (1986) Monoclonal antibodies to human amnion. J. Reprod. Immunol. 9, 11–21.PubMedCrossRefGoogle Scholar
  7. Johnson, P.M. and Faulk, W.P. (1978) Immunological studies of human placentae: identification and distribution of proteins in immature chorionic villi. Immunol. 34, 1027–1035.Google Scholar
  8. Kaufmann, P. (1982) Development and differentiation of the human placental villous tree. In: Structural and Functional Organization of the Placenta, (eds.), P. Kaufmann and B.F. King, London: Karger.Google Scholar
  9. McCormick, J.N., Faulk, W.P., Fox, H., and Fudenberg, H.H. (1971) Immunohisto- logical and elution studies of the human placenta. J. Exp. Med. 133, 1–18.PubMedCentralPubMedCrossRefGoogle Scholar
  10. Moe, N. (1969) Deposits of fibrin and plasma proteins in the normal human placenta: an immunofluorescence study. Acta Pathologica et Microbiologica Scandinavica 76, 74–88.Google Scholar
  11. Moe, N. and Jorgensen, L. (1968) Fibrin deposits on the syncytium of the normal human placenta: evidence of their thrombogenic origin. Acta Pathologica et Microbiologica Scandinavica 72, 519–541.Google Scholar
  12. Ockleford, J.A., Hsi, B.-L., Wakely, J., Badley, R.A., Whyte, A., and Faulk, W.P. (1981) Propidium iodide as a nuclear marker in immunofluorescence. I. Use with tissue and cytoskeleton studies. J. Immunol. Methods 43, 261–267.PubMedCrossRefGoogle Scholar
  13. Sinha, D., Wells, M., and Faulk, W.P. (1984) Immunological studies of human placentae: complement components in pre-eclamptic chorionic villi. Clin. Exp. Immunol. 56,175–184.Google Scholar
  14. Smith, N.C., Brush, M., and Luckett, L. (1974) Preparation of human placental villous surface membranes. Nature 252, 302–303.PubMedCrossRefGoogle Scholar
  15. Yeh, C.-J.G., Hsi, B.-L., and Faulk, W.P. (1981) Propidium iodide as nuclear marker in immunofluorescence. II. Use with cellular identification and viability studies. J. Immunol. Methods 43, 269–275.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Bae-Li Hsi
    • 1
  • Chang-Jing G. Yeh
    • 1
  1. 1.Faculté de MédecineINSERM U210Nice-CedexFrance

Personalised recommendations