Renal Clearance: Measurements of Glomerular Filtration Rate and Renal Blood Flow

  • Esmail Koushanpour
  • Wilhelm Kriz
Chapter

Abstract

In a limited sense the function of the kidney is to remove excess water and solutes as well as waste products of metabolism from the circulating plasma. To accomplish this, the renal corpuscle makes a copious ultrafiltrate of the renal plasma flow (RPF), which subsequently is modified both in volume and in composition by tubular reabsorption and secretion, yielding a small volume of hypertonic urine. Accordingly, the final volume and composition of the excreted urine depends largely on the volume of plasma filtered at the glomerulus (GFR) and on the fraction of renal plasma flow that escaped filtration (RPF-GFR) and was subsequently processed by the tubules.

Keywords

Glomerular Filtration Rate Renal Clearance Renal Blood Flow Extraction Ratio Tubular Reabsorption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Aukland K: Methods for measuring renal blood flow Total flow and regional distribution. Ann Rev Physiol 1980; 42: 543–555.CrossRefGoogle Scholar
  2. 2.
    Bankir L, Trinh Trang Tan MM, Grunfeld JP: Mea-surement of glomerular blood flow in rabbits and rats: Erroneous findings with 15 µm microspheres. Kidney Int 1979; 15: 126–133.PubMedCrossRefGoogle Scholar
  3. 3.
    Barger AC, Herd JA: Renal vascular anatomy and distribution of blood flow, in Orloff J, Berliner RW (eds): Handbook of Physiology, Sec. 8, Renal Phys iology. Washington DC, American Physiological Society, 1973, pp 249–313.Google Scholar
  4. 4.
    Brod J, Sirota JH: Renal clearance of endogenous “creatinine” in man. J Clin Invest 1948; 27: 645–654.PubMedCrossRefGoogle Scholar
  5. 5.
    Chou SY, Spitalewitz S, Faubert PF, et al: Inner med ullary hemodynamics in chronic salt-depleted dogs. Am J Physiol 1984; 246: F146 - F154.PubMedGoogle Scholar
  6. 6.
    Davies DF, Shock NW: Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. J Clin Invest 1950; 29: 496–507.PubMedCrossRefGoogle Scholar
  7. 7.
    De Wardener HE: The Kidney: An Outline of Normal Invest Function. Boston, Little 21. Thorburn GD, Kopald HH, Herd Brown Co, 1958.Google Scholar
  8. 8.
    Earley LE, Friedler RM: Changes in renal blood flow and possibly the intrarenal distribution of blood during the natriuresis accompanying saline loading in the dog. J Clin Invest 1965; 44: 929–941.PubMedCrossRefGoogle Scholar
  9. 9.
    Goldstein MH, Lenz PR, Levitt MF: Effect of urine flow rate on urea reabsorption in man: Urea as a “tu bular marker”. J Appl Physiol 1969; 26: 594–599.PubMedGoogle Scholar
  10. 10.
    Gutman Y, Gottschalk CW, Lassiter WE: Micro-clear-puncture study of inulin absorption in the rat kidney. Science 1965; 147: 753–754.PubMedCrossRefGoogle Scholar
  11. 11.
    Kampmann J, Siersbaek-Nielsen K, Kristensen M, Hansen JM: Rapid evaluation of creatinine clearance. Acta Med Scand 1974; 196: 517–520.PubMedCrossRefGoogle Scholar
  12. 12.
    Katz MA, Blantz RC, Rector FC Jr, Seldin DW: Measurement of intrarenal blood flow. I. Analysis of microsphere method. AmJPhysiol 1971; 220: 1903–1913.Google Scholar
  13. 13.
    Knox FG, Ritman EL, Romero JC: Intrarenal disribution of blood flow: Evaluation of a new approach to measurement. Kidney Int 1984; 25: 473–479.PubMedCrossRefGoogle Scholar
  14. 14.
    McNay JL, Abe Y: Pressure-dependent heterogeneity of renal cortical blood flow in dogs. Circ Res 1970; 27: 571–587.PubMedCrossRefGoogle Scholar
  15. 15.
    Moore CD, Gewertz BL: Measurement of renal blood flow. J Surg Res 1982; 32: 85–95.PubMedCrossRefGoogle Scholar
  16. 16.
    Pitts RF: Physiology of Kidney and Body Fluids, ed 3. Chicago, Year Book Medical Publishers, Inc, 1974.Google Scholar
  17. 17.
    Relman AS, Levinsky NG: Clinical examination of renal function, in Strauss MB, Welt LG (eds): Diseases of the Kidney. Boston, Little Brown Co, 1963.Google Scholar
  18. 18.
    Smith HW: The Kidney-Structure and Function in Health and Disease. New York, Oxford University Press, 1951.Google Scholar
  19. 19.
    Stein J: The renal circulation, in Brenner BM, Rector FC Jr (eds): The Kidney. Philadelphia, WB Saunders Co, 1976, pp 215–250.Google Scholar
  20. 20.
    Steinitz K, Turkland H: Determination of glomerular filtration by endogeous creatinine clearance. J Clin 1940; 19: 285–298.Google Scholar
  21. 21.
    Thoroburn GD, Kopald HH, Herd JA, et al: Intrarenal distribution of nutrient blood flow determined with Krypton in the unanesthetized dog. Circ Res 1963; 13: 290–307.CrossRefGoogle Scholar
  22. 22.
    Tobias JG, McLaughlin RF Jr, Hopper J Jr: Endog-enous creatinine clearance. New Eng J Med 1962; 266: 317–323.PubMedCrossRefGoogle Scholar
  23. 23.
    Van Slyke DD: Renal function tests. New York State J Med 1941; 41: 825–833.Google Scholar
  24. 24.
    Winberg J: 24-hour true endogenous creatinine ance in infants and children without renal disease. ActaPaediat 1959; 48:443–452.Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Esmail Koushanpour
    • 1
  • Wilhelm Kriz
    • 2
  1. 1.Northwestern University Medical SchoolChicagoUSA
  2. 2.University of HeidelbergHeidelbergFederal Republic of Germany

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