Liquid-Solid Sample Preparation

  • R. D. McDowall
  • J. C. Pearce
  • G. S. Murkitt
  • R. M. Lee
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 16 A)

Abstract

Sample preparation is frequently an essential step in the determination of drugs in biological fluids. Until recently the need for selective extraction of analytes has usually been met by liquid-liquid extraction. However, due to recent developments in bonded-silica chemistry an alternative is feasible for many drugs and metabolites. They can be trapped on a solid phase (e.g. C-18 or CN silica), freed from contaminants by washing, then eluted and analyzed chromatographically. Liquid-solid extraction is rapid and of fers good precision and accuracy. It is the basis of two automated sample processors which are commercially available andean notably aid productivity. The capabilities of one of these (‘AASP’) are outlined.

Keywords

HPLC Column Emulsion Formation Quantitative HPLC Analysis Cartridge Polypropylene Elut Cartridge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Schill, G. (1978) Separation Methods for Drugs and Related Organic Compounds, Apotekarsocieteten, Stockholm, 182 pp.Google Scholar
  2. 2.
    Lee, R.M. & McDowall, R.D. (1983) J. Chromatog.275, 377–385.Google Scholar
  3. 3.
    Coates, W.J., Eden, R.J., Emmett, J.C., Gristwood, R.W., Owen, D.A.A., Slater, R.A., Taylor, E.M. & Warrington, B.H. (1985) Br. J. Pharmacol.84, 22p.Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • R. D. McDowall
    • 1
  • J. C. Pearce
    • 1
  • G. S. Murkitt
    • 1
  • R. M. Lee
    • 1
  1. 1.Department of Drug AnalysisSmith Kline & French Research Ltd.Welwyn, Herts.UK

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