Myelin pp 259-310 | Cite as

The Neuropathology of Myelin Diseases

  • Cedric S. Raine


The following terminology (Section II) and classification (Table 1) form the scaffold of both this chapter on neuropathology and the closely integrated chapter (Chapter 9) on the clinical aspects of the myelin diseases. Appropriate naturally occurring and experimental conditions of animals are covered briefly. Naturally occurring disorders of myelin in animals are covered in greater detail in Chapter 14.


Multiple Sclerosis White Matter Progressive Multifoeal Leukoeneephalopathy Progressive Multifocal Leukoencephalopathy Metachromatic Leukodystrophy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Adams, R. D., 1959, Nutritional diseases of the nervous system in the alcoholic patient, Trans. Am. Clin Climatol. Assoc. 71: 59.PubMedGoogle Scholar
  2. Adams, R. D., and Kubik, C. S., 1952, The morbid anatomy of the demyelinatioe diseases, Am. J. Med. 12: 510.PubMedGoogle Scholar
  3. Adams, R. D., and Sidman, R. I., 1968, Introduction to Neuropathology, McGraw-Hill, New York. Aleu, F. P., Katzman, R., and Terry, R. D., 1963, Fine structure and electrolyte analyses of cerebral edema induced by alkyl tin intoxication, J. Neuropathol. Exp. Neurol. 22: 403.Google Scholar
  4. Appel, M. J. G., and Gillespie, J. H., 1972, Canine distemper virus, Virol. Monogr. 10: 1.Google Scholar
  5. Asbury, A. K., Arnason, B. W. G., and Adams, R. D., 1969, The inflammatory lesion in idiopathic polyneuritis, Medicine 48: 173.PubMedGoogle Scholar
  6. Austin, J. H., and Lehfeldt, D., 1965, Studies in globoid (Krabbe) leucodystrophy. III. Significance of experimentally produced globoid-like elements in rat white matter and spleen, J. Neuropathol. Exp. Neurol. 24: 265.PubMedGoogle Scholar
  7. Baker, A. B., and Baker, L. H., 1974, Clinical Neurology, Harper and Row, New York.Google Scholar
  8. Barlow, R. M., and Dickinson, A. G., 1965, On the pathology and histochemistry of central nervous system in border disease of sheep, Res. Vet. Sci. 6: 230.PubMedGoogle Scholar
  9. Behan, P. 0., Geschwind, N., Lamarche, J. B., Lisak, R. P., and Kies, M. W., 1968, Delayed hypersensitivity to encephalitogenic protein in disseminated encephalomyelitis, Lancet 2: 1109.Google Scholar
  10. Berger, B., 1971, Quelques aspects ultrastruct oraux de la substance blanche chez la souris quaking, Brain Res. 25: 35.PubMedGoogle Scholar
  11. Blackwood, W., McMenemey, W. H., Meyer, A., Norman, R. M., and Russel, D. S., 1971, Greenfield’s Neuropathology, E. Arnold, London.Google Scholar
  12. Blakemore, W. F., 1973, Demyelination of the superior cerebellar ptduncle in the mouse induced by Cuprizone, J. Neurol. Sci. 20: 63.PubMedGoogle Scholar
  13. Blaw, M. E., 1970, Melanodermic type leukodystrophy (adrenoleukodystrophy), in: Handbook of Clinical Neurology, Vol. 10 (P. J. Vinken and G. W. Bruyn, eds.), pp. 128: 133, North-Holland, Amsterdam.Google Scholar
  14. Bradley, W. G., and Jenkison, M., 1973, Abnormalities of peripheral nerves in munine muscular dystrophy, J. Neurol. Sci. 18: 227.PubMedGoogle Scholar
  15. Brain. W. R., and Walton, J. N., 1969, Brain’s Deseases of the Nervous System, Oxford University Press, London.Google Scholar
  16. Brun, A., Nordenfelt, E., and Kjellen, L., 1973, Aspects of the variability of progressive multifocal leukoencephalopathy, Acta Neuropathol. (Berlin) 24: 232.Google Scholar
  17. Bunge, R. P., Bunge, M. B., and Ris, H., 1960, Electron microscopic study of demyelination in an experimentally induced lesion in adult and cat spinal cord, J. Biochem. Biophys. Cytol. 7: 685.Google Scholar
  18. Cheever, F. S., Daniels, J. B., Pappenheimer, A. M., and Bailey, O. T., 1919, A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin. I. Isolated and biological properties of the virus, J. Exp. Med. 90: 181.Google Scholar
  19. Crome, L., Tymms, V. and Woolf, L. I., 1962, A chemical investigation of myelination in phenylketonuria, J. Neurol. Neurosurg. Psychiatry 25: 113.Google Scholar
  20. Cummings, J. F., and Haas, D. C., 1967, Coonhound paralysis: An acute idiopathic polyradiculo-neuritis in dogs resembling the Landry-Guillain-Barré syndrome, J. Neurol. Sri. 4: 51.Google Scholar
  21. Dawson, J. W., 1916, The histology of disseminated sclerosis, Trans. R. Soc. Edinburgh 50. Dobbing, J., 1968, Vulnerable periods of developing brain, in: App lied Neurochemistry ( A. N. Davison and J. Dobbing, eds.), pp. 287–316, F. A. Davis, Philadelphia.Google Scholar
  22. Epstein, L. G., Prineas J. W., and Raine, C. S., 1983, Attachment of myelin to coated pits on macrophages in experimental allergic encephalomyelitis, J. Neurol. Sci., 61: 341.PubMedGoogle Scholar
  23. Eylar, E. H., Toro-Goyco, E., Kessler, M. J., and Szymanska, I., 1982, Induction of allergic neuritis in rhesus monkeys, J. Immunol. 3: 91.Google Scholar
  24. Fardeau, M., and Engel, W. K., 1969, IJltrastructural study of a peripheral nerve biopsy in Refsum’s disease, J. Neuropathol. Exp. Neurol. 28: 278.PubMedGoogle Scholar
  25. Fleury, 1–1. J., Sheppard, R. D., Bornstein, M. B., and Raine, C. S., 1980, Further ultrastructural observations of virus morphogenesis and myelin pathology in JHM virus encephalomyelitis, Neuropathol. Appt Neurobiol. 6: 165.Google Scholar
  26. Georgsson, G., Pallson, P. A., Panitch, H., Nathanson, N., and Petursson, G., 1977, The ultrastructure of early visna lesions, Acta Neuropathol. (Berlin) 37: 127.Google Scholar
  27. Georgsson, G., Martin, J. R., Klein, J., Pallson, P. A., Nathanson, N., and Petursson, G., 1982, Primary demyelination in visna, Acta Neuropathol. (Berlin) 57: 171.Google Scholar
  28. Gouatas, N. K., and Howard, J. C., 1974, Inhibition of experimental allergic encephalomyelitis in rats severely depleted of T cells, Science 186: 839.Google Scholar
  29. Haase, A. T., Ventura, P., Gibbs, C. J., and Tourtellotte, W. W., 1981, Measless virus nucleotide sequences: Detection by hybridization in situ, Science 212: 672.PubMedGoogle Scholar
  30. Herndon, R. M., Rubinstein, L. J., Freedman, J. M., and Methieson, G., 1970, Light and electron microscopic observations on Rosenthal fibers in Alexander’s disease and in multiple sclerosis, J. Neuropathol. Exp. Neurol. 29: 524.PubMedGoogle Scholar
  31. Hirano, A., Sax, D. S., and Zimmerman, H. M., 1969, The fine structure of the cerebella of jimpy mice and their “normal” litter mates, J. Neuropathol. Exp. Neurol. 28: 388.Google Scholar
  32. Igarashi, M., Schaumburg, H. H., Powers, J., Kishimoto, Y., Kolodny, E., and Suzuki, K., 1976, Unusual fatty acid abnormality in adrenoleukodystrophy, J. Neurochem. 26: 851.PubMedGoogle Scholar
  33. Iivanainen, M. V., 1981, The significance of abnormal immune responses in patients with multiple sclerosis, J. Immunol. 1:141.Google Scholar
  34. Jervis, G. A., 1963, Pathology of phenylketonuria, in: Phenylketonuria ( F. Lyman, ed.), pp. 96–100, Charles C Thomas, Springfield, Illinois.Google Scholar
  35. Johnson, R. T., and Weiner, L. P., 1972, The role of viral infections in demyelinating diseases, in: Multiple Sclerosis: Immunology, Virology and Ultrastructure ( F. Wolfgram, G. W. Ellison, J. G. Stevens, and J. M. Andrews, eds.), pp. 245–274, Academic Press, New York.Google Scholar
  36. Katzman, R., Aleu, F., and Wilson, C., 1963, Further observations on triethyl tin edema, Arch. Neurol. 9: 178.PubMedGoogle Scholar
  37. Kirk, J., 1979, The fine structure of the central nervous system in multiple sclerosis. II. Vescicular disruption of myelin in an acute case, Neuropathol. Appl. Neurobiol. 5: 289.PubMedGoogle Scholar
  38. Knox, W. E., 1972, Phenylketonuria, in: The Metabolic Basics of Inherited Disease ( J. B. Stanbury, J. B. Wyngaarden, and D. S. Fredrickson, eds.), pp. 226–295, McGraw-Hill, New York.Google Scholar
  39. Lampert, P. W., 1967, Electron microscopic studies on ordinary and hyperacute experimental allergic encephalomyelitis, Acta Neuropathol. (Berlin) 9: 99.Google Scholar
  40. Lampert, P. W., 1969, Mechanism of demyelination in experimantal allergic neuritis, Lab. Invest. 20: 127.PubMedGoogle Scholar
  41. Lampert, P. W., and Schochet, S., 1968, Electron microscopic observations on experimental spongy degeneration of the cerebellar white matter, J. Neuropathol. Exp. Neurol. 27: 210.PubMedGoogle Scholar
  42. Lampert, P., O’Brien, J., and Garrett, R., 1973a, Hexachlorophene encephalopathy, Acta Neuropathol. (Berlin) 23: 326.Google Scholar
  43. Lampert, P. W., Sims, J. K., and Kniazeff, A. J., 1973b, Mechanism of demyelination in JHM virus encephalomyelitis, Acta Neuropathol. (Berlin) 29: 76.Google Scholar
  44. Lyon, G., and Goffinet, A., 1980, Genetics and Pathology of dysmyelinating disorders of the central nervous system: Comparison to animal models, in: Neurological Mutations Affecting Myelination (N. Baumann, ed.), INSERM Symposium No. 14, pp. 33–46, Elsevier North-Holland, Amsterdam.Google Scholar
  45. Malamud, N., 1966, Neuropathology of phenylketonuria, J. Neuropathol. Exp. Neurol. 25: 254.PubMedGoogle Scholar
  46. McFarlin, D. E., and McFarland, H. F., 1982a, Multiple sclerosis, N. Engl. J. Med. 307: 1183.PubMedGoogle Scholar
  47. McFarlin, D. E., and McFarland, H. F., 1982b, Multiple sclerosis, N. Engl. J. Med. 307: 1246.PubMedGoogle Scholar
  48. Meier, C., and Bischoff, A., 1974, Dysmyelination in “jimpy” mouse: Electron microscopic study, J. Neuropathol. Exp. Neurol. 33: 343.PubMedGoogle Scholar
  49. Meier, C., Herschkowitz, N., and Bischoff, A., 1974, Morphological and biochemical observations in the jimpy spinal cord, Acta Neuropathol. (Berlin) 27: 349.Google Scholar
  50. Merritt, H. H., and Weisman, A. D., 1945, Primary degeneration of the corpus callosum (MarchiafavaBignami’s disease), J. Neuropathol. Exp. Neurol. 4: 155.Google Scholar
  51. Morell, P., Bornstein, M. B., and Raine, C. S., 1981, Diseases involving myelin, in: Basic Neurochemistry, 3rd ed. ( G. J. Siegel, R. W. Albers, R. Katzman, and B. W. Agranoff, eds.), pp. 641–658, Little, Brown, Boston.Google Scholar
  52. Moser, H. W., 1970, Sulfatide lipidosis: Metachromatic leukodystrophy, in: The Metabolic Basis of Inherited Disease ( J. B. Stanbury, J. B. Wyngaarden, and D. S. Fredrickson, eds.), pp. 688–729, McGraw-Hill, New York.Google Scholar
  53. Norenberg, M. D., Leslie, K. O., and Robertson, A. S., 1981, Association between rise in serum sodium and central pontine myelinolysis, Ann. Neural. 11:128.Google Scholar
  54. Norrby, E., Link, H., and Olsson, J. E., 1974, Measles virsus antibodies in multiple sclerosis, Arch. Neural. 30: 285.Google Scholar
  55. Ochoa, J., Fowler, T. J., and Gilliatt, R. W., 1972, Anatomical changes in peripheral nerves compressed by a pneumatic tourniquet, J. Anat. (London) 113: 433.Google Scholar
  56. Padgett, B. L., Walker, D. I,., Zu Rhein, G. M., Eckroade, R. J., and Dessel, B. H., 1971, Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy, Lancet 1: 1257.Google Scholar
  57. Pant, S. S., Asbury, K., and Richardson, E. P., 1968, ‘The myelopathy of pernicious anemia Acta Neurol. Scand. 44 (Suppl. 35).Google Scholar
  58. Paterson, P. Y., 1973, Multiple sclerosis: An immunologic reassessment, J. Chronic Dis. 26:119. Pfeiffer, J., 1970, Metachromatic leucodystrophy, in: Handbook of Clinical Neurology, Vol. 10 ( P. J. Vinken and G. W. Bruyn, eds.), pp. 43–66, North-Holland, Amsterdam.Google Scholar
  59. Perier, O., and Gregoire, A., 1965, Electron microscopic features of multiple sclerosis lesions Brain 88:937.Google Scholar
  60. Petursson, C;., Nathanson, N., Georgsson, G., Panitch, H., and Pallson, P. A., 1976, Pathogenesis of visna. I. Sequential virologie, serologic and pathologic studies, Lab. Invest. 35:402.Google Scholar
  61. Pleasure, D., Towfighi, J., Silberberg, D., and Parris, J., 1974, The pathogenesis of hexachlorophene neuropathy: in vivo and in vitro studies, Neurology 24:2068.Google Scholar
  62. Plum, F., Posner, J. B., and Hain, P. F., 1962, Delayed neurological deterioration after anoxia, Arch. Intern. Med. 110:18.Google Scholar
  63. Powell, H., Swarner, O., Gluck, L., and Lampert, P., 1973, Hexachlorophene myclinopathy in premature infants, J. Pediatr. 82: 976.PubMedGoogle Scholar
  64. Prineas, J. W., 1971, Acute idiopathic polyneuritis: An electron microscope study, Lab. Invest. 26: 34.Google Scholar
  65. Prineas, J. W., 1972, Paramyxovirus-like particles associated with acute demyelination in chronic relapsing multiple sclerosis, Science 178: 760.PubMedGoogle Scholar
  66. Prineas, J. W., 1975, Pathology of the early lesions in multiple sclerosis, Hum. Pathol. 6: 531.Google Scholar
  67. Prineas, J. W., and Connell, F., 1978, The fine structure of chronically active multiple sclerosis plaques, Neurology 28: 68.PubMedGoogle Scholar
  68. Prineas, J. W., and Connell, F., 1979, Remyelination in multiple sclerosis, Ann. Neurol. 5: 22.Google Scholar
  69. Prineas, J. W., and Graham, J, S., 1981, Multiple sclerosis: Capping of surface immunoglobulin G on macrophages engaged in myelin breakdown, Ann. Neurol. 10: 149.Google Scholar
  70. Prineas, J. W., and MacLeod, J. M., 1976, Chronic relapsing polyneuritis, J. Neurol. Sci. 27: 427.PubMedGoogle Scholar
  71. Prineas, J. W., and Raine, C. S., 1976, Electron microscopy and immunoperoxidase studies of early multiple sclerosis lesions, Neurology 26 (Suppl.): 29.PubMedGoogle Scholar
  72. Prineas, J. W., and Wright, R. G., 1972, The fine structure of peripheral nerve lesions in a virus-induced demyelinatiog disease in fowl (Marek’s disease), Lab. Invest. 26: 548.PubMedGoogle Scholar
  73. Prineas, J. W., and Wright, R. G., 1978, Macrophages, lymphocytes, and plasma cells in the perivascular compartment in chronic multiple sclerosis, Lab. Invest. 38: 409.PubMedGoogle Scholar
  74. Raine, C. S., 1972, Viral infections on nervous tissue and their relevance to multiple sclerosis, in: Multiple Sclerosis: Immunology, Virology, and Ultrastructure ( F. Wolfgram, G. W. Ellison, J. G. Stevens, and J. M. Andrews, eds.), pp. 91–218, Academic Press, New York.Google Scholar
  75. Raine, C. S., 1976a, Experimental allergic encephalomyelitis and related conditions, in: Progress in Neuropathology Vol. 3 ( H. M. Zimmerman, ed.), pp. 225–251, Grune & Stratton, New York.Google Scholar
  76. Raine, C. S., 1976b, On the development of lesions in natural canine distemper. J. Neural, Sci. 30: 13.Google Scholar
  77. Raine, C. S., 1977. Disorders of myelin, in: Biological Handbooks. II. Human Health and Disease ( P. L. Altman and D. D. Katz, eds.), pp. 246–256, Federation of American Societies for Experimental Biology, Bethesda, Maryland.Google Scholar
  78. Raine, C. S., 1978, Membrane specialisations between demyelinated axons and astroglia in chronic EAE lesions and multiple sclerosis plaques, Nature (London) 275: 326.Google Scholar
  79. Raine, C. S., 1982, Multiple sclerosis and chronic relapsing EAE: Comparative ultrastructural neuropathology, in: Multiple Sclerosis: The Patient, the Disease, and the Treatment,“ (J. Hallpike, C. W. M. Adams, and W. W. Tourtellotte, eds.), pp. 411–458, Chapman and Hall, London.Google Scholar
  80. Raine, C. S., and Stone, S. H., 1977, Animal model for multiple sclerosis: Chronic experimental allergic encephalomyelitis in inbred guinea pigs, N. Y. State J. Med. 77:1693.Google Scholar
  81. Raine, C. S., and Traugott, U., 1982, The pathogenesis and therapy of multiple sclerosis is based upon the requirement of a combination of myelin antigens for autoimmune demyelination, J. Neuroimmunol. 2: 83.PubMedGoogle Scholar
  82. Raine, C. S., Snyder, D. H., Valsamis, M. P., and Stone, S. H., 1974, Chronic experimental allergic encephalomyelitis in inbred guinea pigs—An ultrastructural study, Lab. Invest. 31:369.Google Scholar
  83. Raine, C. S., Schaumburg, H. H., Snyder, D. H„ and Suzuki, K., 1975, Intranuclear “paramyxovirus-like” material in multiple sclerosis, adrenoleukodystrophy and Kuf’s disease, J. Neurol. Sci. 25: 29.PubMedGoogle Scholar
  84. Raine, C. S., Barnett, L. B., Brown, A., Behar, T., and McFarlin, D. E., 1980, Neuropathology of experimental allergic encephalomyelitis in inbred strains of mice, Lab. Invest. 43: 150.PubMedGoogle Scholar
  85. Raine, C. S., Scheinberg, L. C., and Waltz, J. M., 1981, Multiple sclerosis: Oligodendrocyte survival and proliferation in an active, established lesion, Lab. Invest. 45: 534.PubMedGoogle Scholar
  86. Raine, C. S., Traugott, U., and Stone, S. H., 1982, Suppression and treatment of chronic relapsing encephalomyelitis, in: Multiple Sclerosis, East and West ( Y. Kuroiwa and L. T., Kurland, eds.), pp. 359–374, Kyushu University Press, Fukuoka, Japan.Google Scholar
  87. Rawlins, F. A., and Uzman, B. G., 1970a, Retardation of peripheral nerve myelination in mice treated with inhibitors of cholesterol biosynthesis: A quantitative electron microscopic study, J. Cell. Biol. 46: 505.PubMedGoogle Scholar
  88. Rawlins, F. A., and Uzman, B. G., 19706, Effect of AY-9944, a cholesterol biosynthesis inhibitor, on peripheral nerve myelination, Lab. Invest. 23: 184.Google Scholar
  89. Schaumburg, H. H., 1983, Clinical and pathological studies of adrenoleukodystrophy (ALD) and adrenomyelinoneuropathy (AMN), in: International Symposium on Leukodystrophy and Allied Diseases, (T. Yonezawa, ed.) pp. 203–209, Jap. Soc. Neuropath., Kyoto.Google Scholar
  90. Schaumburg, H. H., Richardson, E. P., Johnson, P. C., Cohen, R. B., Powers, J. M., and Raine, C. S., 1972, Schilder’s disease: Sex-linked recessive transmission with specific adrenal changes, Arch. Neurol. 27: 458.PubMedGoogle Scholar
  91. Schaumburg, H. H., Powers, J. M., Raine, C. S., Suzuki, K., and Richardson, E. P., Jr., 1975, Adreno-leukodystrophy: A clinical and pathological study of seventeen cases, Arch. Neurol. 33: 577.Google Scholar
  92. Seitelberger, F., 1970, Pelizaeus-Merzbacher disease, in: Handbook of Clinical Neurology, Vol. 10 ( P. J. Vinken and G. W. Bruyn, eds.), pp. 128–133, North-Holland, Amsterdam.Google Scholar
  93. Sidman, R. L., and Hayes, R., 1965, Jimpy: A mouse with inherited sudanophilic leukodystrophy, J. Neuropathol. Exp. Neurol. 24: 172.Google Scholar
  94. Sidman, R. L., Dickie, M. M., and Appel, S. H., 1964, Mutant mice (quaking and jimpy) with deficient myelination in the central nervous system, Science 144: 309.PubMedGoogle Scholar
  95. Solcher, H., 1973, Veber Hirnveranderungen bei Heredopathia atactica polyneuritiformis (Refsum), Acta Neuropathol. (Berlin) 24: 92.Google Scholar
  96. Spencer, P. S., Weinberg, H. J., Raine, C. S., and Prineas, J. W., 1975, The perineurial window—A new model of focal demyelination and remyelination, Brain Res. 96: 323.PubMedGoogle Scholar
  97. Steinberg, D., 1972, Phytanic acid storage disease: Refsum’s syndrome, in: The Metabolic Basis of Inherited Disease ( J. B. Stanbury, J. B. Wyngaarden, and D. S. Fredrickson, eds.), pp. 833–853, McGraw-Hill, New York.Google Scholar
  98. Suzuki, K., 1983, Biochemistry of adrenoleukodystrophy: A review, in: International Symposium on Leukodystrophy and Allied Diseases, (T. Yonezawa ed.), Jap. Soc. Neuropath, Kyoto, pp. 239–246.Google Scholar
  99. Suzuki, K., Suzuki, Y., and Eto, Y., 1971, Deficiency of galactocerebroside beta-galactosidase in Krabbe’s globoid cell leucodystrophy, in: Lipid Storage Diseases, ( J. Bernsohn and H. J. Grossman eds.), pp. 111–136, Academic Press, New York.Google Scholar
  100. Suzuki, K. I., 1970, Ultrastructural study of experimental globoid cells, Lab. Invest. 23: 612.PubMedGoogle Scholar
  101. Suzuki, K. I., Andrews, J. M., Waltz, J. M., and Terry, R. D., 1969, Ultrastructural studies of multiple sclerosis, Lab. Invest. 20: 444.PubMedGoogle Scholar
  102. Suzuki, K. I., and Kikkawa, Y., 1969, Status spongiosus of CNS and hepatic changes induced by Cuprizone (bicyclohexanone oxalyldihydrazone), Am. J. Pathol. 54: 307.PubMedGoogle Scholar
  103. Suzuki, K. I., and Zagoren, J. C., 1974, Degeneration of oligodendroglial cells in the central nervous system of rats treated with AY-9944 or triparanol, Lab. Invest. 31: 503.PubMedGoogle Scholar
  104. Suzuki, Y., and Suzuki, K., 1971, Krabbe’s globoid cell leukodystrophy: Deficiency of galactocerebrosidase in serum, leukocytes and fibroblasts, Science 171: 73.PubMedGoogle Scholar
  105. Suzuki, Y., Austin, J., Armstrong, D., Suzuki, K., Schlenker, J., and Fletcher, T., 1970, Studies in globoid leukodystrophy: Enzymatic and lipid findings in the canine form, Exp. Neurol. 29: 65.PubMedGoogle Scholar
  106. Ter Meulen, V., Koprowski, H., Iwasaki, H., Kackell, Y. M., and Muller, D., 1972a, Fusion of cultured multiple-sclerosis brain cells with indicator cells: Presence of nucleocapsids and virions and isolation of parainfluenza-type I virus, Lancet 2: 1.PubMedGoogle Scholar
  107. Ter Meulen, V., Muller, D., Kackell, Y., Katz, M., and Meyermann, R., 1972b, Isolation of infectious measles virus in measles encephalitis, Lancet 1: 1172.Google Scholar
  108. Terry, R. D., 1970, Electron microscopy of selected neurolipidoses, in: Handbook of Clinical Neurology, Vol. 10 ( P. J. Vinken and G. W. Bruyn, eds.), pp. 362–384, North-Holland, Amsterdam.Google Scholar
  109. Traugott, U., Snyder, D. S., and Raine, C. S., 1979, Oligodendrocyte staining by multiple sclerosis serum is nonspecific. Ann. Neurol. 6: 13.PubMedGoogle Scholar
  110. Traugott, U., Scheinberg, L. C., and Raine, C. S., 1981, Lymphocyte responsiveness to oligodendrocytes in multiple sclerosis, J. Neuroimmunol. 1: 41.PubMedGoogle Scholar
  111. Traugott, U., Stone, S. H., and Raine, C. S., 1982a, Chronic relapsing experimental autoimmune encephalomyelitis: Treatment with combinations of myelin components promotes clinical and structural recovery, J. Neurol. Sci. 56: 65.PubMedGoogle Scholar
  112. Traugott, U., Reinherz, E. L., and Raine, C. S., 1982b, Monoclonal anti-T cell antibodies are applicable to the study of inflammatory infiltrates in the central nervous system, J. Neuroimmunol. 3:365. Traugott, U., Reinherz, E. L., and Raine, C. S., 1983, Multiple sclerosis: Distribution of T cell subsets within active chronic lesions, Science 219: 308.Google Scholar
  113. Van Bogaert, L., 1970, Spongy degeneration of the brain, in: Handbook of Clinical Neurology, Vol. 10 ( P. J. Vinken and G. W. Bruyn, eds.), pp. 203–211, North-Holland, Amsterdam.Google Scholar
  114. Volk, B. W., and Adachi, M., 1970, Diffuse cerebral sclerosis—Krabbe type, in: Handbook of Clinical Neurology, Vol 10 ( P. J. Vinken and G. W. Bruyn, eds.), pp. 67–93, North-Holland, Amsterdam.Google Scholar
  115. Waksman, B. H., and Adams, R. D., 1956, Comparative study of experimental allergic neuritis in the rabbit, guinea pig, and mouse, J. Neuropathol. Exp. Neurol. 15: 293.PubMedGoogle Scholar
  116. Waksman, B. H., and Adams, R. D., 1962, Infectious leukoencephalitis: A critical comparison of certain experimental and naturally-occurring viral leukoencephalitides with experimental allergic encephalomyelitis, J. Neuropathol. Exp. Neurol. 21: 491.PubMedGoogle Scholar
  117. Watanabe, I., McCaman, R., Dyken, P., and Zeman, W., 1969, Absence of cerebral myelin sheaths in a case of presumed Pelizaeus-Merzbacher disease, J. Neuropathol. Exp. Neurol. 28: 243.PubMedGoogle Scholar
  118. Watanabe, I., Patel, V., Goebel, H. H., Siakotos, A. N., Zeman, W., DeMyer, W., and Dyer, J. S., 1973, Early lesions of Pelizaeus-Merzbacher disease: Electron microscopic and biochemical study, J. Neuropathol. Exp. Neurol. 32: 313.PubMedGoogle Scholar
  119. Webster, H. de F., Spiro, D., Waksman, B., and Adams, R. D., 1961, Phase and electron microscope studies of experimental demyelination. II. Schwann cell changes in guinea pig sciatic nerves during experimental diphtheritic neuritis, J. Neuropathol. Exp. Neurol. 20: 5.PubMedGoogle Scholar
  120. Weinberg, H. J., Spencer, P. S., and Raine, C. S., 1975, Aberrant PNS development in dystrophic mice, Brain Res. 88: 532.PubMedGoogle Scholar
  121. Weiner, L. P., Herndon, R. M., Narayan, O., Johnson, R. T., Shah, K., Rubinstein, L. J., Preziosi, T. J., and Conley, F. K., 1972, Isolation of virus related to SV40 from patients with progressive multifocal leukoencephalopathy, N. Engl. J. Med. 286: 385.PubMedGoogle Scholar
  122. Weller, R. 0., 1965, Diphtheritic neuropathy in the chicken: An E. M. study, J. Pathol. Bacteriol. 89:591. Wisniewski, H., and Morell, P., 1971, Quaking mouse: Ultrastructural evidence for arrest of myelinogenesis, Brain Res. 29: 63.Google Scholar
  123. Wisniewski, H., and Raine, C. S., 1971, An ultrastructural study of experimental demyelination and remyelination. V. Central and peripheral nervous system lesions caused by diphtheria toxin, Lab. Invest. 25: 73.PubMedGoogle Scholar
  124. Wisniewski, H., Raine, C. S., and Kay, W. J., 1972, Observations on viral demyelinating encephalomyelitis: Canine distemper, Lab. Invest. 26: 589.PubMedGoogle Scholar
  125. Wolfe, H. J., and Pietra, G. G., 1964, The visceral lesions of metachromatic leukodystrophy, Am. J. Pathol. 44: 921.PubMedGoogle Scholar
  126. Yunis, E. J., and Lee, R. F., 1969, The ultrastructure of globoid (Krabbe) leukodystrophy, Lab. Invest. 21: 415.Google Scholar
  127. Zu Rhein, G. M., 1969, Association of papova-virius with a human demyelinating disease (progressive multifocal leukoencephalopathy), Prog. Med. Viral. 11: 185.Google Scholar
  128. Zu Rhein, G. M., and Chou, S. M., 1965, Particles resembling papovaviruses in human cerebral demyelinating disease, Science 148: 1477.Google Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Cedric S. Raine
    • 1
    • 2
  1. 1.Departments of Pathology (Neuropathology) and NeuroscienceAlbert Einstein College of MedicineThe BronxUSA
  2. 2.The Rose F. Kennedy Center for Research in Mental Retardation and Human DevelopmentAlbert Einstein College of MedicineThe BronxUSA

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