The Comparative Pathology of Nonhuman Primate Atherosclerosis

  • Thomas B. Clarkson
  • Mary S. Anthony
  • Robert W. Prichard
Chapter

Abstract

The ideal animal model for atherosclerosis research would develop the lesions gradually during its lifetime and would develop clinical manifestations of the disease in late middle and old age. The atherosclerotic lesions of the ideal model would range from trivial abnormalities, such as fatty streaks, found only at necropsy, to raised plaques with complications such as ulceration, stenosis, hemorrhage and superimposed thrombosis. The number of animals developing such complicated lesions would ideally constitute about 20% of the population, with males developing complications more frequently than females, particularly in the coronary arteries. The clinically-significant lesions would be found first in the aorta, later in the coronary arteries and later still in the arteries supplying the brain. The end-organ complications of myocardial and cerebral infarction and gangrene of the extremities would be seen. Aneurysm formation in the aorta would develop occasionally. All of these things should take place in an animal sufficiently large to allow diagnostic and therapeutic measurements similar to those useful for human beings.

Keywords

Rhesus Monkey Cynomolgus Monkey African Green Monkey Fatty Streak Vervet Monkey 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Thomas B. Clarkson
    • 1
  • Mary S. Anthony
    • 1
  • Robert W. Prichard
    • 1
  1. 1.Arteriosclerosis Research Center, Bowman Gray School of MedicineWake Forest UniversityWinston-SalemUSA

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