The Effects of Regional Hypoxia on the Distribution of Pulmonary Blood Flow
When a part of the lung is made hypoxic, the perfusion of that part diminishes and is redirected to the non-hypoxaemic part. Experiments demonstrating this phenomenon have usually been done by cannulating one bronchus, using a Carlens catheter and then ventilating one lung with 211 oxygen and the other with perhaps 10% oxygen measuring the pulmonary blood flow on the hypoxic side using the Fick principle. Whilst such an experiment is rather invasive and the precision of measurement was not high it was sufficient to confirm the hypothesis that alveolar hypoxaemia led to blood diversion.
KeywordsResidual Volume Pulmonary Blood Flow Dependant Part Regional Hypoxia Airway Closure
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