Principles of Management Pertaining to Renal Pathology

  • James E. Wenzl
Chapter

Abstract

It is an established fact that no other branch of medicine has undergone as rapid or as astonishing an amount of growth as has the field of nephrology during the past two decades. In 1960, the field was characterized by a loose association of anatomists, physiologists, pathologists, and internists who were interested in the structure and function of the kidney in health and disease. They were soon joined by a small but growing group of immunologists and pediatricians who were chiefly concerned with renal immunopathogenic and pathophysiologic mechanisms. The main thrust of the specialty concerned itself with diagnosis of renal disease and treatment of the pathophysiologic consequences of the various forms of renal dysfunction.

Keywords

Systemic Lupus Erythematosus Nephrotic Syndrome Lupus Nephritis Renal Lesion Idiopathic Nephrotic Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Baldwin, D. S., Lowenstein, J., Rothfield, N., Gallo, G., and McCluskey, R. T.: The clinical course of the proliferative and membranous forms of lupus nephritis. Ann. Intern. Med. 73: 929, 1970.PubMedGoogle Scholar
  2. Bardana, E. J., Jr., Porter, G. A., Pirofsky, B., Gourley, R. T., and Bayrakci, C.: Azathioprine in steroid-insensitive nephropathy. Am. J. Med. 49: 789, 1970.PubMedCrossRefGoogle Scholar
  3. Barratt, T. M., Bercowsky, A., Osofsky, S. G., and Soothill, J. F.: Cyclophosphamide treatment in steroid-sensitive nephrotic syndrome of childhood. Lancet 1: 55, 1975.PubMedCrossRefGoogle Scholar
  4. Beliel, O. M., Coburn, J. W., Shinaberger, J. N., and Glassock, R. J.: Recurrent glomerulonephritis due to antigomerular basement membrane antibodies in two successive allografts. Clin. Nephrol. 1: 377, 1973.Google Scholar
  5. Black, D.: Trials of treatment of glomerulonephritis. Contr. Nephrol. 2: 175, 1976.Google Scholar
  6. Booth, L. J., and Aber, G. W.: Immunosuppressive therapy in adults with proliferative glomerulonephritis. Lancet 2: 1010, 1970.PubMedCrossRefGoogle Scholar
  7. Cade, R., Spooner, G., Schlein, E., Pickering, M., DeQuesada, A., Holcomb, A., Juncos, L., Richard, G., Shires, D., Levin, D., Hackett, R., Free, J., Hunt, R., and Fregly, M.: Comparison of azathioprine, prednisone and heparin alone or combined in treating lupus nehpritis. Nephron 10: 37, 1973.PubMedCrossRefGoogle Scholar
  8. Cameron, J. S.: The natural history of glomerulonephritis. In Renal Disease, 2nd ed. ( D. A. K. Black, ed.). Blackwell, Oxford, 1972, p. 295.Google Scholar
  9. Cameron, J. S.: A clinician’s view of the classification of glomerulonephritis. In Glomerulonephritis: Morphology, Natural History, and Treatment ( P. Kincaid-Smith, T. H. Matthew, and E. L. Becker, eds.). Wiley, New York, 1973, p. 63.Google Scholar
  10. Cameron, J. S., Ogg, C. S., Turner, D. R., Willer, R. O., White, R. H.R., Glasgow, E. F., Peters, D. K., and Martin, A.: Mesangiocapillary glomerulonephritis and persistent hypocomplementemia. In Glomerulonephritis: Morphology, Natural History, and Treatment, Part 1 ( P. Kincaid-Smith, T. H. Matthew, and E. L. Becker, eds.). Wiley, New York, 1973, p. 591.Google Scholar
  11. Cameron, J. S., Turner, D. R., Ogg, C. S., Sharpstone, P., and Brown, C. B.: The nephrotic syndrome in adults with “minimal change” glomerular lesions. Q. J. Med. 43: 461, 1974.PubMedGoogle Scholar
  12. Cathcart, E. S., Scheinberg, M. A., Idelson, B. A., and Couser, W. G.: Beneficial effects of methylprednisolone “pulse” therapy in diffuse proliferative lupus nephritis. Lancet 1: 163, 1976.PubMedCrossRefGoogle Scholar
  13. Chiu, M. B., McLaine, P. N., and Drummond, K. N.: A controlled prospective study of cyclophosphamide in relapsing, corticosteroid-responsive, minimal-lesion nephrotic syndrome in childhood. J. Pediatr. 82: 607, 1973.PubMedCrossRefGoogle Scholar
  14. Couser, W. G.: Goodpasture’s syndrome: A response to nitrogen mustard. Am. J. Med. Sci. 268: 175, 1974.PubMedCrossRefGoogle Scholar
  15. Decker, J. L., Klippel, J. H., Plotz, P. H., and Steinberg, A. D.: Cyclophosphamide or azathioprine in lupus glomerulonephritis. Ann. Intern. Med. 83: 606, 1975.PubMedGoogle Scholar
  16. Dillard, M. G., Dujoune, I., Pollak, V. E., and Pirani, C. L.: The effect of treatment with prednisone and nitrogen mustard on the renal lesions and life span of patients with lupus glomerulonephritis. Nephron 10: 273, 1973.PubMedCrossRefGoogle Scholar
  17. Friedman, E. A., Delano, B. G., and Butt, K. M. H.: Pragmatic realities in uremia therapy. N. Engl. J. Med. 298: 368, 1978.PubMedCrossRefGoogle Scholar
  18. Ginzler, E., Sharon, E., Diamond, H., and Kaplan, D.: Long-term maintenance therapy with azathioprine in systemic lupus erythematosus. Arthritis Rheum. 18: 27, 1975.PubMedCrossRefGoogle Scholar
  19. Grupe, W. E.: Chlorambucil in steroid-dependent nephrotic syndrome. J. Pediatr. 82: 598, 1973.PubMedCrossRefGoogle Scholar
  20. Habib, R., and Kleinknecht, C.: Idiopathic extramembranous glomerulonephritis in children. In Glomerulonephritis: Morphology, Natural History, and Treatment, Part 1 ( P. Kincaid-Smith, T. H. Matthew, and E. L. Becker, eds.). Wiley, New York, 1973, p. 449.Google Scholar
  21. Hahn, B. H., Kantor, O. S., and Osterland, C. K.: Azathioprine plus prednisone compared with prednisone alone in the treatment of systemic lupus erythematosus. Ann. Intern. Med. 83: 597, 1975.PubMedGoogle Scholar
  22. Holaman, R. E., Hutt, M. P., Brittain, R. S., and Hammond, A. S.: Goodpasture’s syndrome: Treatment failure with azathioprine. J. Am. Med. Assoc. 196: 31, 1966.Google Scholar
  23. Holland, N. H., and Bennett, N. M.: Hypocomplementemic (membranoproliferative) glomerulonephritis. Immunosuppressive therapy. Am. J. Dis. Child. 123: 439, 1972.PubMedGoogle Scholar
  24. Kallen, R. J., and Lewis, E. J.: Immunosuppressive treatment of chronic glomerulonephritis. J. Pediatr. 82: 335, 1973.PubMedCrossRefGoogle Scholar
  25. Kincaid-Smith, P.: Mesangiocapillary glomerulonephritis. In Glomerulonephritis: Morphology, Natural History, and Treatment ( P. Kincaid-Smith, T. H. Matthew, and E. L. Becker, eds.). Wiley, New York, 1973, p. 591.Google Scholar
  26. Kjellstrand, C. M.: Transplantation in systemic disease and familial-congenital disorders. Dial. Transplant. 7: 151, 1978.Google Scholar
  27. Levinsky, R. S., Mullenson, P. N., Barratt, T. M., and Soothhill, J. F.: Circulating immune complexes in steroid-responsive nephrotic syndrome. N. Engl. J. Med. 298: 126, 1978.PubMedCrossRefGoogle Scholar
  28. Lindeman, R. D.: Corticosteroid and immunosuppressive therapy of idiopathic nephrotic syndrome. J. Oklahoma Med. Assoc. 64: 449, 1971.Google Scholar
  29. Lindeman, R. D., Pederson, J. A., Matter, B. J., Laughlin, L. O., and Mandal, A. K.: Long-term azathioprine-corticosteroid therapy in lupus nephritis and idiopathic nephrotic syndrome. J. Chronic Dis. 29: 189, 1976.PubMedCrossRefGoogle Scholar
  30. Lockwood, C. M., Boulton-Jones, J. M., Wilson, C. B., and Peters, D. F.: Plasmapheresis: The role of this new technique in the recovery of a patient with Goodpasture’s syndrome and severe renal failure. VI. International Congress on Nephrology, Florence, Italy, 1975.Google Scholar
  31. McAdams, A. J., McEnery, P. T., and West, C. D.: Mesangiocapillary glomerulonephritis: Changes in glomerular morphology with long-term alternate-day prednisone therapy. J. Pediatr. 86: 23, 1975.PubMedCrossRefGoogle Scholar
  32. Richet, G.: Controlled clinical trials and glomerulonephritis. Contr. Nephrol. 2: 184, 1976.Google Scholar
  33. Schutz, W., Batsford, S. R., Jesdinsky, H. J., Kluthe, R., and Schollmeyer, P.: Controlled multicenter trial on the natural history and treatment of glomerulonephritis (using indomethacin and cyclophosphamide) preliminary results. Contr. Nephrol. 2: 180, 1976.Google Scholar
  34. Schwartz, M. W., Schwartz, G. J., and Cornfeld, D.: A 16-year follow-up study of 163 children with nephrotic syndrome. Pediatrics 54: 547, 1974.PubMedGoogle Scholar
  35. Seaton, A., Meland, J. M., and Lapp, N. L.: Remission in Goodpasture’s syndrome: Report of two patients treated by immunosuppression and review of the literature. Thorax 26: 683, 1971.PubMedCrossRefGoogle Scholar
  36. West, C. D., Holland, N. H., McConville, J. M., and McAdams, A. J.: Immunosuppressive therapy in persistent hypocomplementemic glomerulonephritis and lupus nephritis. J. Pediatr. 67: 1113, 1965.CrossRefGoogle Scholar

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© Springer Science+Business Media New York 1979

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  • James E. Wenzl

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