Dose, Dose Rate, Radiation Quality, and Host Factors for Radiation-Induced Life Shortening

  • George A. Sacher

Abstract

This paper reviews the effects of ionizing radiations on disease incidence and life shortening in experimental animals, with the aim of establishing a phenomenological model of the dose and time kinetics for the production of late radiation damage. Aspects of this problem have been discussed previously (Sacher, 1956a). At that time, mammalian cellular radiology had barely begun its dramatic development, and there were no experimental data against which to test the hypothesis adopted then, that the phenomena of radiation life shortening are due to chromosome breakage and rejoining. This hypothesis was stated most explicitly by Muller (1950), but it was also implicit in the discussion of lethal effects in cells by Lea (1947), and in a real sense it was a development that epitomized the classical period of radiation genetics.

Keywords

Fast Neutron Linear Energy Transfer High Daily Dose Gompertz Function Thymic Lymphoma 
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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • George A. Sacher
    • 1
  1. 1.Division of Biological and Medical ResearchArgonne National LaboratoryArgonneUSA

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