Energetics and Mechanism of 2-Aminopurine Induced Mutations

  • Robert Rein
  • Ramon Garduno

Abstract

Template specified base selection in nucleic acid synthesis underlies the expression of the genetic code. This comprises the storage replication and processing of information embedded in the chromosomal base sequences and is fundamental for the dynamics of the living state of matter. The fidelity of the gene copying is manifested in an error discrimination of the order of one error in 106−109 replicated bases /1/. What gives the fidelity to this selection specificity has intrigued physicists from the early days of genetics. To explain the stability of the genetic code, Delbruck /2/ and Schrödinger /3/ have considered the genome to be in a stationary quantum state. The discovery of the double helical structure of the DNA by Watson, Crick and Wilkins /4,5/ has provided the structural basis for a more explicit physical theory of the genetic code.

Keywords

Genetic Code Relative Probability Tautomeric Form Pairing Scheme Base Analog 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Robert Rein
    • 1
    • 2
  • Ramon Garduno
    • 1
    • 2
  1. 1.Department of Experimental PathologyRoswell Park Memorial InstituteBuffaloUSA
  2. 2.Department of BiophysicsState University of New York at BuffaloBuffaloUSA

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