Structural and Functional Properties of Consecutive Enzymes in the Glycolytic Pathway
In this article I will outline the basic mechanistic features of triosephosphate dehydrogenase (GPD), phosphoglycerate kinase (PGK) and phosphoglycerate mutase (PGM); enzymes whose structures have been studied by me and by my coworkers over many years. Emphasis will be placed on the properties of these enzymes which appear to be functionally important as seen from the static — snap shot — type pictures observed using the analysis of X-ray diffraction data. The information provided will show that great strides have been made towards our understanding of the enzymic processes involved but that much remains to be done to confirm the proposed reaction mechanisms.
KeywordsPhosphoryl Group Phosphoglycerate Mutase Propose Reaction Mechanism Phosphoryl Transfer Covalent Intermediate
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