Peptidic and Proteic Substances Isolated from Pineals and Their Relation to the Hypophysial-Hypothalamic-Gonadal Axis

  • I. Ebels
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 65)

Abstract

At the ultrastructural level, processes implicated in the synthesis and release of peptidic/proteic compounds have been clearly identified in pineal specific cells (Collin, 1979, 1981; Collin and Oksche, 1981; Pévet, 1979, 1981a,b, 1982a,b). Thus the synthesis and release of peptidic/proteic substances cannot be discarded. The isolation, purification and characterization of this class of pineal compounds have however presented a formidable challenge, since extraction methods for peptide purification have failed to yield large quantities of pure compounds, sufficient for structure elucidation. Moreover, a simple and specific bioassay, indispensable for the isolation of biologically active compounds has not been available till now. Different observations however support the presence of pineal peptidic and proteic substances showing a definite biological activity.

Keywords

Luteinizing Hormone Pineal Gland Pineal Organ Pineal Body Tropic Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • I. Ebels
    • 1
  1. 1.Department of Organic ChemistryState University of UtrechtThe Netherlands

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