Influence of the Pineal Gland on Tumor Growth in Mammalians: A Reappraisal from a Biochemical Point of View

  • Maria E. Ferioli
  • Giuseppe Scalabrino
  • Franco Fraschini
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 65)

Abstract

The regulation of the growth of mammalian tumors by different hormones remains an intriguing mystery. The claim that the pineal gland is involved in controlling neoplastic growth is one segment of that large area.

Keywords

Mammary Gland Pineal Gland Neoplastic Growth Yoshida Sarcoma Human Pineal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Andersson, A. C., Henningsson, S., Lundell, L., Rosengren, E., and Sund I er, F., 1976, Diamines and Polyamines in DMBA-Induced Breast Carcinoma Containing Mast Cells Resistant to Compound 48/80, Agents and Actions 6: 577.Google Scholar
  2. Aubert, C., Jan i aud, P., and Leca l vez, J., 1980, Effect of Pinealectomy and Melatonin on Mammary Tumor Growth in Sprague-Dawley Rats Under Different Conditions of Lighting, J. Neural Transm. 47: 121.Google Scholar
  3. Barone, R. M., and Das Gupta, T. K., 1970, Role of Pinealectomy on Walker 256 Carcinoma in Rats, J. Surg. Oncol. 2:313.Google Scholar
  4. Bartsch, H., and Bartsch, C., 1981, Effect of Melatonin on Experimental Tumors Under Different Photope-riods and Times of Administration, J. Neural Transm. 52:269.Google Scholar
  5. B i ndon i, M. Jut i sz, M., and Ribot, G., 1976, Character-ization and Partial Purification of a Substance in the Pineal Gland Which Inhibits Cell Multi-plication In Vitro, Biochim. Biophys. Acta 437:577.Google Scholar
  6. Buswell, R. S., 1975, The Pineal and Neoplasia, Lancet :34.Google Scholar
  7. Cohen, M., Lippman, M., and Chabner, B., 1978, Role of Pineal Gland in Aetiology and Treatment of Breast Cancer, Lancet ii:814.Google Scholar
  8. Das Gupta, T. K., and Terz, J., 1967a, Influence of Pineal Body on Melanoma of Hamsters, Nature 2/3:1038.Google Scholar
  9. Das Gupta, T. K., and Tèrz, J., 1967b, Influence of Pineal Gi nd. on the Growth and Spredd of Melanoma in the Hamster, Cancer Res. 27: 1306.Google Scholar
  10. Dilman, V. M., Anisimov, V. N., Ostroumova, M. N., Morosov, V. G., Khavinson, V. K., and Azarova, M. A., 1979, Study of the Anti-Tumor Effect of Polypeptide Pineal Extract, Oncology 36: 274.Google Scholar
  11. EI-Domeiri, A. A. H., and Das Gupta, T. K., 1973, Reversal by Melatonin of the Effect of Pinealectomy on Tumor Growth, Cancer Res. 33: 2830.Google Scholar
  12. Geiger, P. J., and Bessman, S. P., 1972, Protein Determination by Lowry’s Method in the Presence of Sulfhydryl Reagents, Anal. Biochem. 49:467.Google Scholar
  13. Hajdu, S. I., Porro, R. S., Lieberman, P. H., and Foote, F. W., Jr., 1972, Degeneration of the Pineal Gland of Patients with Cancer, Cancer 29: 706.Google Scholar
  14. Hamilton, T., 1969, Influence of Environmental Light and Melatonin Upon Mammary Tumour Induction, Brit. J. Surg. 56:764.Google Scholar
  15. Hoffman, R. A., and Reiter, R. J., 1965, Rapid Pinealectomy in Hamsters and Other Small Rodents, Anat. Rec. 153:19.Google Scholar
  16. Huxley, M., and Tapp, E., 1972a, Effects of B i ogen i c Amines on the Growth of Rat Tumors, Life Sci. 11 (Part lí):19.Google Scholar
  17. Huxley, M., and Tapp, E., 19726, The Histochemical Measurements of the Lipid Content of the Pineal Gland in Rats Suffering from Malignancy, Brain Res., 37: 123.Google Scholar
  18. Jânne, J., and Williams-Ashman, H. G., 1971, On the Purification of Ornithine Decarboxylase from Rat Ventral Prostate and Effects of Thiol Compounds on the Enzyme, J. Biol. Chem. 246:1725.Google Scholar
  19. Karmali, R. A., Horrobin, D. F., and Ghayur, T., 1978, Role of Pineal Gland in Aetiology and Treatment of Breast Cancer, Lancet ii:1001.Google Scholar
  20. Lapin, V., 1975, The Pineal and Neoplasia, Lancet i:341.Google Scholar
  21. Lapin, V., 1978, Effects of Reserpine on the Incidence of 9,10-Dimethyl-1,2-benzanthracene-induced Tumors in Pinealectomised and Thymectomised Rats, Oncology 35: 132.Google Scholar
  22. Lapin, V., and Ebels, I., 1976, Effects of Some Low Molecular Weight Sheep Pineal Fractions and Melatonin on Different Tumors in Rats and Mice, Oncology 33: 110.Google Scholar
  23. Lapin, V., and Ebels, I., 1981, The Role of the Pineal Gland in Neuroendocrine Control Mechanisms of Neoplastic Growth, J. Neural Transm. 50:275.Google Scholar
  24. Lapin, V., and Frowein, A., 1981, Effects of Growing Tumours on Pineal Melatonin Levels in Male Rats, J. Neural Transm. 52:123.Google Scholar
  25. Rodin, A. E., 1963, The Growth and Spread of Walker 256 Carcinoma in Pineale’ctomized Rats, Cancer Res. 23:1545.Google Scholar
  26. Rodin, A. E., and Overall, J., 1967, Statistical Relationships of Weight of the Human Pineal to Age and Malignancy, Cancer 20: 1203.Google Scholar
  27. Scalabrino G., and Ferioli, M. E., 1981, Polyamines in Mammalian Tumors, Part I, Adv. Cancer Res. 35:151.Google Scholar
  28. Scalabrino, G., Ferioli, M. E., Nebuloni, R., and Fraschini, F., 1979, Effects of Pinealectomy on the Circadian Rhythms of the Activities of Polyamine Biosynthetic Decarboxylases and Tyrosine Amino-transferase in Different Organs of the Rat, Endocrinology 104: 377.Google Scholar
  29. Scalabrino, G., P5só, Hr., H5lttg, E., Hannonen, P., Kallio, A., and JSnne, J., 1978, Synthesis and Accumulation of Polyamines in Rat Liver During Chemical Carcinogenesis, Int. J. Cancer 21:239.Google Scholar
  30. Sneider, T. W., and Potter, V. R., 1969, Deoxycytidylate Deaminase and Related Enzymes of Thymidine Triphosphate Metabolism in Hepatomas and Precan-cerous Rat Liver, Adv. Enzyme Regul. 7:375.Google Scholar
  31. Tamarkin, L., Cohen, M., Roselle, D., Reichert, C., Lippman, M., and Chabner, B., 1981, Melatonin Inhibition and Pinealectomy Enhancement of 7,12-Dimethylbenz(a)anthracene-induced Mammary Tumors in the Rat, Cancer Res. 41: 4432.Google Scholar
  32. Tapp, E., and B l umf i e I d, M., 1970, The Weight of the Pineal Gland in Malignancy, Brit. J. Cancer 24:67.Google Scholar
  33. Tapp, E., 1980a, The Human Pineal Gland in Malignancy, J. Neural Transm. 48:119.Google Scholar
  34. Tapp, E., 19806, Pineal Gland in Rats Suffering from Malignancy, J. Neural Transm. 48:131.Google Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Maria E. Ferioli
    • 1
  • Giuseppe Scalabrino
    • 1
  • Franco Fraschini
    • 1
  1. 1.Institute of General Pathology and C.N.R. Center for Research in Cell Pathology (M.E.F., G.S.) and Institute of Pharmacology, Chair of Chemotherapy (F.F.)University of MilanMilanoItaly

Personalised recommendations