The Effect of Glucose upon Reabsorptive Transport of Urate by the Kidney

  • Geoffrey Boner
  • Richard E. Rieselbach
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41)


The mechanism of the increase in urinary excretion of urate following hyperglycemia has been variously interpreted by different workers (1,2,3,4,5). Hyperglycemia and/or its consequences, in all probability inhibit the tubular reabsorption of urate. This inhibitory effect may be the result of:
  1. 1)

    the elevation of blood sugar per se,

  2. 2)

    an increase in filtered load of glucose with an associated acceleration of reabsorptive transport in that segment of the proximal tubule where glucose is primarily reabsorbed, or

  3. 3)

    the presence of glucose in tubular fluid in a distal segment of the proximal tubule in a concentration substantially greater than that usually present.



Glomerular Filtration Rate Proximal Tubule Plasma Glucose Level Kidney Donor Oral Glucose Load 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1).
    Talbott, J.H.: Gout., Oxford Medicine, Vol. IV Oxford University Press, New York, 1943, p.108.Google Scholar
  2. 2).
    Bonsnes, R.W. and Dana, E.S.: On the Increased Uric Acid Clearance Following the Intravenous Infusion of Hypertonic Glucose Solution. J. Clin. Invest., 25: 386, 1946.CrossRefGoogle Scholar
  3. 3).
    Christensen, P.J. and Steenstrup, O.R.: Uric Acid Excretion with Increasing Glucose Concentration (pregnant and non-pregnant cases). Scan. J. Clin. & Lab. Invest., 10: 182, 1958.CrossRefGoogle Scholar
  4. 4).
    Padova, J., Patchefsky, A., Onesti, G., Faludi, G. and Bendersky, G.: The Effect of Glucose Loads on Renal Uric Acid Excretion in Diabetic Patients. Metab., 13:507, 1964.Google Scholar
  5. 5).
    Herman, J.B. and Keynan, A.: Hyperglycemia and Uric Acid. Israel J. Med. Sci., 5:1048, 1969.PubMedGoogle Scholar
  6. 6).
    Maher, F.T., Nolan, N.G. and Elveback, L.R.: Comparison of Simultaneous Clearances of 1125 Labelled Iothalamate (Glofil) and Inulin. Mayo Clin. Proc., 46:690, 1971.PubMedGoogle Scholar
  7. 7).
    Slein, M.W.: Methods of Enzymatic Analysis, Bergmeyer, H.V. Ed., Academic Press, New York 1963, p.117.Google Scholar
  8. 8).
    Liddle, L., Seegmiller, J.E. and Laster, L.: The Enzymatic Spectrophotometric Method for Determination of Uric Acid. J. Lab. & Clin. Med., 54:903, 1959.Google Scholar
  9. 9).
    Smith, H.W.: Principles of Renal Physiology, Oxford University Press, New York, 1956, p.196.Google Scholar
  10. 10).
    Skeith, M.D., Healey, L.A. and Cutler, R.E.: Urate excretion During Mannitol and Glucose Diuresis. J. Lab. & Clin. Med., 70:213, 1967Google Scholar
  11. 11).
    Steele, T.H. and Boner, G.: Origins of the Uricosuric Response. J. Clin. Invest., In press.Google Scholar

Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • Geoffrey Boner
    • 1
  • Richard E. Rieselbach
    • 1
  1. 1.Nephrology ProgramUniversity of Wisconsin Medical SchoolMadisonUSA

Personalised recommendations