Effects of Benzofuran Derivatives on Tubular Permeability to Urate-2-14C in the Rat Nephron

  • Ronald A. Kramp
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41 B)

Abstract

It is generally admitted that renal excretion of urate may involve a three component system: glomerular filtration and tubular reabsorption and/or secretion (1). Tubular microinjection experiments in the rat kidney showed that urate was essentially reabsorbed along the proximal tubule presumably by a carrier-mediated mechanism. Under these experimental conditions a secretory process for urate could not be shown nor excluded (2). In an attempt to further unravel some of the uncertainties related to these transport mechanisms we have investigated the effects of benzofuranne derivatives on urate transport along the rat nephron. Rats were pretreated with benzbromarone or benziodarone which are two potent uricosuric drugs in man (3,4).

Keywords

Proximal Tubule Distal Tubule Urate Transport Micropuncture Study Benzofuran Derivative 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Gutman A.B. and Yü T.F. — A three component system for regulation of renal excretion of uric acid in man. Trans. Ass. Amer. Phycns 74: 353, 1961.Google Scholar
  2. 2.
    Kramp R.A., Lassiter W.E. and Gottschalk C.W. — Urate-2-14C transport in the rat nephron. J. clin. Invest. 50: 35, 1971.PubMedCrossRefGoogle Scholar
  3. 3.
    Sternon J., Kocheleff P., Couturier E., Baiasse E. and Van den Abeele P. — Effet hypouricémiant de la benzbromarone. Etude de 24 cas. Acta Clin. Belg. 22: 285, 1967.Google Scholar
  4. 4.
    Podevin R., Paillard F., Amiel C. and Richet G. — Action de la benziodarone sur l’excrétion rénale de l’acide urique. Rev. franc. Etud. clin. biol. 12: 361, 1967.PubMedGoogle Scholar
  5. 5.
    Gottschalk C.W., Morel F. and Mylle M. — Tracer microinjection studies of renal tubular permeability. Amer. J. Physiol. 209: 173, 1965.PubMedGoogle Scholar
  6. 6.
    Gutman Y., Gottschalk C.W. and Lassiter W.E. — Micropuncture study of inulin reabsorption in the rat kidney. Science 147: 753, 1965.PubMedCrossRefGoogle Scholar
  7. 7.
    Morel F., Mylle M. and Gottschalk C.W. — Tracer microinjection studies of effect of ADH on renal tubular diffusion of water. Amer. J. Physiol. 209: 179, 1965.PubMedGoogle Scholar
  8. 8.
    Arrizurieta-Muchnik E.E., Lassiter W.E., Lipham E.M. and Gottschalk C.W. — Micropuncture study of glomerulotubular balance in the rat. Nephron 6: 418, 1969.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • Ronald A. Kramp
    • 1
  1. 1.Department of MedicineUniversity of Louvain School of MedicineLouvainBelgium

Personalised recommendations