Effects of Benzofuran Derivatives on Tubular Permeability to Urate-2-14C in the Rat Nephron

  • Ronald A. Kramp
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41)


It is generally admitted that renal excretion of urate may involve a three component system: glomerular filtration and tubular reabsorption and/or secretion (1). Tubular microinjection experiments in the rat kidney showed that urate was essentially reabsorbed along the proximal tubule presumably by a carrier-mediated mechanism. Under these experimental conditions a secretory process for urate could not be shown nor excluded (2). In an attempt to further unravel some of the uncertainties related to these transport mechanisms we have investigated the effects of benzofuranne derivatives on urate transport along the rat nephron. Rats were pretreated with benzbromarone or benziodarone which are two potent uricosuric drugs in man (3,4).


Proximal Tubule Distal Tubule Urate Transport Micropuncture Study Benzofuran Derivative 
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Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • Ronald A. Kramp
    • 1
  1. 1.Department of MedicineUniversity of Louvain School of MedicineLouvainBelgium

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