Uricosuric Effect of an Anticholinergic Agent in Hyperuricemic Subjects

  • A. E. Postlethwaite
  • C. M. Ramsdell
  • W. N. Kelley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41 B)

Abstract

In recent years there has been an appreciable expansion of our understanding of secondary hyperuricemia and of certain rare subtypes of gout associated with an excessive production of uric acid. Although the pathogenesis of primary hyperuricemia in most subjects remains obscure, it is clear that many such patients have a diminished renal clearance of uric acid (Wyngaarden and Kelley, 1972). The factor(s) responsible for this abnormal clearance has been difficult to define since our understanding of the manner in which the kidney of normal man regulates uric acid excretion is incomplete.

Keywords

Uric Acid Fractional Excretion Anticholinergic Agent Uric Acid Excretion Serum Urate Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Gutman, A. B., Yu, T. F. and Berger, L. 1969. Renal function in gout. III. Estimation of tubular secretion and reabsorption of uric acid by use of pyrazinamide. Amer. J. Med. 47: 575–592.PubMedCrossRefGoogle Scholar
  2. Lieber, C. S., Jones, D. P., Losowsky, M. S. and Davidson, C. S. 1962. Interrelation of uric acid and ethanol metabolism in man. J. Clin. Invest. 41: 1863–1870.PubMedCrossRefGoogle Scholar
  3. Rieselback, R. E., Sorensen, L. E., Shelp, W. D. and Steele, T. H. 1970. Diminished renal urate secretion per nephron as a basis for primary gout. Ann. Intern. Med. 73: 359–366.CrossRefGoogle Scholar
  4. Schirmeister, J., Mau, N. K. and Hallaner, W. 1969. Study on renal and extrarenal factors involved in the hyperuricemia induced by furosemide, p. 59. In G. Peters and F. Rach-Ramel (eds), Progress in Nephrology, Springer-Verlag, Inc., Berlin.Google Scholar
  5. Steele, T. H. and Oppenheimer, S. 1969. Factors affecting urate excretion following diuretic administration in man. Amer. J. Med. 47: 564–574.PubMedCrossRefGoogle Scholar
  6. Wyngaarden, J. B. and Kelley, W. N. 1972. Gout, pp. 889–968. In J. B. Stanbury, J. W. Wyngaarden, and D. S. Fredrickson (eds.), The metabolic basis of inherited disease, McGraw-Hill Book Company, New York.Google Scholar

Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • A. E. Postlethwaite
    • 1
  • C. M. Ramsdell
    • 1
  • W. N. Kelley
    • 1
  1. 1.Department of MedicineDuke University Medical CenterDurhamUSA

Personalised recommendations