Allopurinol and Thiopurinol : Effect in vivo on Urinary Oxypurine Excretion and Rate of Synthesis of their Ribonucleotides in Different Enzymatic Deficiencies

  • C. Auscher
  • N. Mercier
  • C. Pasquier
  • F. Delbarre
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41 B)

Abstract

At the present time, we just report some experimental results of a study on the mechanism of action of allopurinol (4-hydroxypyrazolo (3,4-d) pyrimidine) and thiopurinol (4 thiopyrazolo (3,4-d) pyrimidine) on de novo biosynthesis of uric acid. In this present work, we have compared effect of allo and thiopurinol on oxypurine (xanthine and hypoxanthine) urinary excretion with their rate of synthesis of ribonucleotides in vitro by erythrocyte hemolysate in some particular enzymatic deficiencies (hypoxanthineguanine phosphoribosyltransferase: HGPRT, adenine phosphoribosyltransférase: APRT and xanthinuria).

Keywords

Urinary Excretion Normal Renal Function Enzymatic Deficiency Erythrocyte Hemolysate Complete Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • C. Auscher
    • 1
  • N. Mercier
    • 1
  • C. Pasquier
    • 1
  • F. Delbarre
    • 1
  1. 1.Centre de Recherches sur les Maladies Ostéo-articulairesUnité No5 INSERM. ERA 337 CNRS. Clinique de Rhumatologie Médicale et Sociale Hôpital CochinParisFrance

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