Effects of Allopurinol and Oxonic Acid on Pyrimidine Metabolism in the Pig

  • P. J. Hatfield
  • H. A. Simmonds
  • J. S. Cameron
  • A. S. Jones
  • A. Cadenhead
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41 B)

Abstract

Pigs given allopurinol showed an increase in urinary orotic acid and orotidine excretion from a mean of 5 mg to a mean of 50 mg/24 hours. Although the dose of allopurinol was constant the levels of orotic acid and orotidine fell gradually from their initial peak. When the drug was stopped levels returned rapidly to normal. These results are similar to those obtained in rat and man (1), where this effect has been attributed to inhibition of the enzyme orotidylic decarboxylase (2).

Keywords

Urinary Excretion Renal Damage Proportional Increase Urinary Level Initial Peak 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • P. J. Hatfield
    • 1
    • 2
  • H. A. Simmonds
    • 1
    • 2
  • J. S. Cameron
    • 1
    • 2
  • A. S. Jones
    • 1
    • 2
  • A. Cadenhead
    • 1
    • 2
  1. 1.Guy’s Hospital and Rowett Research InstituteLondonUK
  2. 2.Guy’s Hospital and Rowett Research InstituteBucksburn, AberdeenshireUK

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