Efficacy of Single Daily Dose Allopurinol in Gouty Hyperuricemia

  • Gerald P. Rodnan
  • James A. Robin
  • Sanford F. Tolchin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41 B)

Abstract

During the past ten years, since its introduction by Rundles and his colleagues, allopurinol has gained widespread favor in the treatment of gout and other hyperuricemic states (1). Although it is conventional to prescribe allopurinol in multiple divided doses each day, the drug is metabolized in man in such a way as to suggest that a single daily dose may prove equally effective.

Keywords

Control Period Serum Urate Single Daily Dose Gouty Arthritis Serum Urate Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Rundles, R.W., Wyngaarden, J.B., Hitchings, G.H., Elion, G.B., and Silberraan, H.R. Trans. Assoc. Amer, Physicians, 76: 126–140 1963.Google Scholar
  2. 2.
    Elion, G.B., Kovensky, A., Hitchings, G.H., Metz, E., and Rundles, R.W. Biochem Pharmacol. 15: 863–880, 1966.PubMedCrossRefGoogle Scholar
  3. 3.
    Elion, G.B., Yü, T.F., Gutraan, A.B., and Hitchings, G.H. Amer. J. Med. 45: 69–77, 1968.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • Gerald P. Rodnan
    • 1
  • James A. Robin
    • 1
  • Sanford F. Tolchin
    • 1
  1. 1.Division of Rheumatology and Clinical Immunology, Department of MedicineUniversity of PittsburghPittsburghUSA

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