Experimental Hyperuricemia in Rats

  • R. Bluestone
  • J. R. Klinenberg
  • J. Waisman
  • L. S. Goldberg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41 B)

Abstract

Renal Disease is a well recognized complication of gout, and the typical histologic features of chronic gouty nephropathy have been carefully studied, however, early evolution of the nephropathy and its precise relationship to hyperuricemia and uricosuria have been difficult to study in the human subject. Unfortunately, animal models of sustained hyperuricemia are difficult to produce and maintain. Recently, Stavric and colleagues described the production of hyperuricemia and urate nephropathy in rats fed orally with oxonic acid and uric acid. oxonic acid is a potent, hepatic uricase inhibitor; and this chemical, combined with uric acid or RNA dietry supplements, consistently leads to hyperuricemia in this species.

Keywords

Uric Acid Solubilised Tissue Individual Metabolic Cage Plasma Urate Urate Deposition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • R. Bluestone
    • 1
    • 2
  • J. R. Klinenberg
    • 1
    • 2
  • J. Waisman
    • 1
    • 2
  • L. S. Goldberg
    • 1
    • 2
  1. 1.Medical Service, VA-Wadsworth Hospital Center, Depts of MedicineCedars-Sinai Medical CenterL.A.USA
  2. 2.UCLA School of MedicineL.A.USA

Personalised recommendations