Increased Biliary Glutathione Disulfide (GSSG) Release in Chronically Ethanol-Treated Rats

  • Osvaldo R. Koch
  • Elba Martino
  • Alberto Boveris
  • Helmut Sies
Chapter

Abstract

Recently, we have reported the observation of a substantial increase in biliary glutathione disulfide (GSSG) concentration in chronically ethanol-treated rats as compared to isocalorically pair-fed controls (Sies et al., 1979). Such information may be relevant to the discussion of liver damage related to chronic alcohol intake. The long-standing dispute in the literature regarding the occurrence of lipid peroxidation in alcoholism (cf. Plaa & Witschi, 1976) may become resolved when experimental approaches of non-invasive and non-destructive nature become increasingly employed. In this respect, GSSG release into bile may prove to be a particularly useful tool, complementing the method of measurement of alkane exhalation (Riely et al., 1974; Köster et al., 1977; Litov et al., 1978) and the new developments in the detection of ultraweak chemiluminescence (cf. Chance et al., 1978, for an overview).

Keywords

Bile Flow Chronic Ethanol Butyl Hydroperoxide Chronic Alcohol Intake Hepatic Lipid Peroxidation 
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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Osvaldo R. Koch
    • 1
  • Elba Martino
    • 2
  • Alberto Boveris
    • 2
  • Helmut Sies
    • 3
  1. 1.Centro de Patologia Experimental, II Catedra de PatologiaUniversidad de Buenos AiresBuenos AiresArgentina
  2. 2.Instituto de Quimica BiologicaUniversidad de Buenos AiresBuenos AiresArgentina
  3. 3.Institut für Physiologische Chemie, Physikalische Biochemie und ZellbiologieUniversität MünchenMünchenGermany

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