Phospholipids pp 287-290 | Cite as

Hexadecylphosphocholine (D-18506): A New Phospholipid with Highly Selective Antitumor Activity

  • W. Schumacher
  • J. Stekar
  • P. Hilgard
  • J. Engel
  • H. Eibl
  • C. Unger

Abstract

Ether lipids have several biological functions as important components of mammalian cells. Considerable interest has recently focussed on the “platelet activating factor” (PAF; 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine), which seems to be of pathogenic importance in the mediation of allergic and inflammatory reactions. A number of analogs of PAF whithout platelet aggregating activity are cytotoxic for a variety of cell types3. Racemic 1-octadecyl-2-methyl-glycero-3-phosphocholine (Et-18-0CH3; INN: Edelfosine) was the prototype in this class of new anti-cancer agents to undergo preclinical evaluation.

Keywords

Mammary Tumor Platelet Activate Factor Mammary Carcinoma Human Leukemia Cell Polymorphonuclear Neutrophil 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Berger, M., Muschiol, C., Schmähl, D., Unger, C. and Eibl, H., 1985, Chemotherapeutische Studien zur Struktur-Wirkungs-Beziehung zytotoxischer Alkylphospholipide an chemisch induzierten Mammacarcinomen der Ratte, in: “Aktuelle Onkologie 34 — Die Zellmembran als Angriffspunkt der Tumorthérapie”, Unger, C., Eibl, H., Nagel, GA. eds., W. Zuckschwerdt, Munich, p. 27–36.Google Scholar
  2. 2.
    Fleer, E.A.M., Unger, C., Kim, D.J., Eibl, H., 1987, Metabolism of Ether Phospholipids ans Analogs in Neoplastic Cells, Lipids 22:856–861.PubMedCrossRefGoogle Scholar
  3. 3.
    Hoffmann D.R., Hajdu, J., Snyder, F., 1984, Cytotoxicity of platelet activating factor and related alkyl-phospholipid analogs in human leukemia cells, polymorphonuclear neutrophils, and skin fibroblasts, Blood 63:545–552.Google Scholar
  4. 4.
    Unger, C., Eibl, H., Nagel, GA., von Heyden, HW., Breiser, A., Engel, J., Stekar, J., Peukert, M., Berger, M., 1989, Hexadecylphosphocholine in the Topical Treatment of Skin Métastases: A Phase I Trial, Contrib. Oncol. 37:219–223.Google Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • W. Schumacher
    • 1
  • J. Stekar
    • 1
  • P. Hilgard
    • 1
  • J. Engel
    • 1
  • H. Eibl
    • 2
  • C. Unger
    • 3
  1. 1.ASTA Pharma AGFrankfurt 1Germany
  2. 2.Max-Planck-InstitutGöttingenGermany
  3. 3.University HospitalGöttingenGermany

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