Therapeutic Properties of Phosphatidylserine in the Aging Brain
The structural and regulatory function of phospholipids in biological membranes has stimulated investigation on the pharmacological properties of these compounds, particularly at cerebral level. In the aging brain, changes in lipid composition or content have been related to alterations of cerebral membranes, such as reduction of membrane fluidity and enzymatic activities, loss of receptors and decreased efficiency of signal transduction mechanisms (21). This has led to the proposal that administration of endogenously occurring phospholipids may preserve the structural and functional integrity of central nervous system membranes, and prevent or reverse neuronal dysfunctions that occur in the course of aging, and age-associated neurodegenerative disorders. In addition, administered phospholipids may participate in phospholipid metabolism, yielding biologically active intermediates in response to physiopathological phenomena (22).
KeywordsCholinergic Neuron Basal Forebrain Escape Latency Spatial Memory Deficit Aged Rodent
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