Inhibitory Interneurons can Rapidly Phase-Lock Neural Populations
The discovery of correlated trains of action potentials in the visual system (Eckhorn et al., 1988; Gray and Singer, 1989; Gray et al., 1989) has been long awaited (Sejnowski, 1986). The well-established existence of rhythms in field potentials recorded from the surface of the brain, or even the skull, would be difficult to explain if the responses of single neurons were not, under some circumstances, entrained to a common firing pattern. More surprising is the observation that neurons that are unlikely to have direct excitatory connections appear to be phase-locked; that is, they fire action potentials within a few milliseconds of each other (Gray et al., 1989). Regardless of the functional significance of these correlations, their existence requires a physical explanation. In a complex, highly nonlinear system of neurons, phase-locking can occur through a variety of mechanisms (Eckhorn et al., 1990; Kammen et al., 1990; Konig and Schillen, 1991a; 1991b; Sporns et al., 1991). One particular mechanism, explored in this chapter, is entrainment and phase-locking through a common, inhibitory interneuron. Inhibition could be effective in entraining pyramidal neurons in local circuits, as we demonstrate here with computer simulations.
KeywordsPyramidal Neuron Model Neuron Synaptic Input Inhibitory Interneuron Apical Dendrite
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