Structural Investigations on the G-Binding Domain of p21
Ever since the ras gene product, p21, was discovered, it became clear, that it is a guanine nucleotide binding protein with significant homology to other G-binding proteins such as protein biosynthesis factors and signal-transducing G-proteins (Barbacid, 1987). Also, a lot of circumstantial evidence suggests that p21 is involved in a growth promoting signaltransduction pathway.
KeywordsDissociation Rate Constant Guanine Nucleotide Binding Protein Ribose Ring 4ppm Downfield Aromatic Portion
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