ras Oncogenes pp 243-253 | Cite as

Ras-Transformed Cells Contain Microtubules Rich in Modified α-Tubulin in Their Trailing Edges

  • A. R. Prescott
  • R. Magrath
  • R. M. Warn

Summary

The distribution of microtubules rich in acetylated α-tubulin has been examined in a variety of transfected, transformed cell lines expressing, either reversibly or constitutively, ras oncoproteins. These cell lines all show large numbers of cell processes or ‘tails’ rich in acetylated tubulin microtubule bundles. The incidence of these bundles correlated with p21 oncoprotein expression. This microtubule distribution was very different from that seen in the untransformed varients of the cells examined where acetylated microtubules were predominently perinuclear. This difference may be of general significance in distinguishing motile cells from non-motile ones.

Keywords

Stress Fibre Mouse Mammary Tumour Virus EC816 Cell Microtubule Bundle Ethane Sulphonic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • A. R. Prescott
    • 1
  • R. Magrath
    • 1
  • R. M. Warn
    • 1
  1. 1.School of Biological SciencesUniversity of East AngliaNorwichUK

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