Animal Models: Importance in Research on Hemorrhage and Thrombosis
Despite some sentiments against animal research, animal models continue to be important in studying hemorrhage and thrombosis. Examples of genetic models are dogs and pigs with von Willebrand’s disease. The homozygous von Willebrand pig appears to be resistant to arteriosclerosis, presumably due to impairment of the platelet aggregating function. Among acquired models, pigs are gaining in favor, perhaps because their clotting and platelet characteristics resemble those in humans. Species vary markedly in their normal plasma levels of platelet aggregating factor/von Willebrand factor (PAF/vWF). One promising approach to the study of thrombosis is using platelet anti-aggregating drugs to inhibit PAF/vWF dependent platelet thrombus formation; a drug-induced von Willebrand state seems feasible.
KeywordsHemorrhagic Disease Normal Plasma Level Pulmonary Thrombosis Impaired Animal Platelet Aggregate Factor
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- 1.ANIMAL MODELS OF THROMBOSIS AND HEMORRHAGIC DISEASES. Cosponsored by the National Heart and Lung Institute and the Institute of Laboratory Animal Resources, National Academy of Sciences. Washington, DC, National Institutes of Health, 1975.Google Scholar
- 2.THE FUTURE OF ANIMALS, CELLS, MODELS, AND SYSTEMS IN RESEARCH, DEVELOPMENT, EDUCATION, AND TESTING. Proceedings of a Symposium, Institute of Laboratory Animal Resources, Division of Biological Sciences, Assembly of Life Sciences. Washington, DC, National Academy of Sciences, 1977.Google Scholar
- 5.McDonald RI, Shepro D, Rosenthal M, Booyse FM: Properties of cultured endothelial cells. SER HAEMATOL VI, 4: 469–478, 1973.Google Scholar
- 10.Seager SWJ: Cost-effectiveness: Utilization of a sperm bank in animal breeding colonies. In ANIMAL MODELS OF THROMBOSIS AND HEMORRHAGIC DISEASE. Co-sponsored by the National Heart and Lung Institute and the Institute of Laboratory Animal Resources, National Academy of Sciences. Washington, DC, National Institutes of Health, 1975, p. 118.Google Scholar
- 22.Fuster V, Bowie EJW, Josa M, Kaye MP: Atherosclerosis in normal and von Willebrand pigs receiving a high cholesterol diet: Control and cross-aortic transplantation studies. CIRCULATION (Suppl) (In Press).Google Scholar
- 23.Bustad LK, McClellan RO, Burns MP (editors): SWINE IN BIOMEDICAL RESEARCH. Richland, Wash., Battelle-Northwest, 1966.Google Scholar
- 26.Lewis JH, Phillips LL, Hann C: Coagulation and hematological studies in primative Australian mammals COMP BIOCHEM PHYSIOL 25: 1129–1135, 1968.Google Scholar
- 34.Geratz JD, Tidwell RR, Brinkhous KM, Mohammed SF, Dann 0, Loewe H: Specific inhibition of platelet agglutination and aggregation by aromatic amidino compounds. THROMB HAEMOSTAS (In Press).Google Scholar