Substrate and Energy Metabolism of the Heart

  • L. H. Opie
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 34)

Abstract

The purpose of the energy metabolism of the heart is to provide an adequate supply of high-energy phosphate compounds to replace the continuous use of ATP in contraction, in ionic exchange processes, and to a lesser extent in other energy-demanding procsses. Because of the very high turnover rate of ATP in the myocardium, a correspondingly high rate of mitochondrial production of ATP is required. Within the mitochondria, the citrate cycle of Krebs breaks down the critical compound acetyl CoA to CO2 and hydrogen atoms; the latter in turn yield electrons which are conveyed along the electron transmitter chain to yield ATP by oxidative phosphorylation, before finally combining with oxygen to form water.

Keywords

Free Fatty Acid Pyruvate Dehydrogenase Phosphatidyl Choline Glycolytic Flux Citrate Cycle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media Dordrecht 1984

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  • L. H. Opie

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