In Vitro Studies on Chemical Carcinogenesis in BALB/c 3T3 Cells
During the last decade many in vitro systems have been developed as short-term tests for chemical, viral and physical carcinogenesis. A complete battery of such tests should include bacterial and mammalian mutagenesis, chromosome tests, DNA repair and cell transformation. These tests have been developed on the assumption that the oncogenic event is based on a genotoxic mechanism, the endpoint of which is detectable in a qualitative or quantitative way in each system.
KeywordsTransformation Frequency Chemical Carcinogen Chemical Carcinogenesis Mouse Embryo Fibroblast Cell Chromosome Test
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