In Vitro Studies on Chemical Carcinogenesis in BALB/c 3T3 Cells

  • Enrico Cortesi
Chapter

Abstract

During the last decade many in vitro systems have been developed as short-term tests for chemical, viral and physical carcinogenesis. A complete battery of such tests should include bacterial and mammalian mutagenesis, chromosome tests, DNA repair and cell transformation. These tests have been developed on the assumption that the oncogenic event is based on a genotoxic mechanism, the endpoint of which is detectable in a qualitative or quantitative way in each system.

Keywords

Transformation Frequency Chemical Carcinogen Chemical Carcinogenesis Mouse Embryo Fibroblast Cell Chromosome Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Enrico Cortesi
    • 1
  1. 1.Laboratory of Experimental Pathology, Division of Cancer Cause and PreventionNational Cancer InstituteFrederickUSA

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