Cellular Studies on Patients with an Unusual Clinical Sensitivity to Ionizing Radiation
There are people in the population who show an unusual sensitivity to ionizing radiation compared with normal individuals. This effect has been demonstrated in the course of bona fide radiotherapy for malignant conditions in these patients with the result proving either lethal to the patient or subsequently giving rise to tumors in the irradiated field. These individuals are members of a small group with inherited disorders showing a predisposition to malignant disease. Although some attempts have been made to study the variation in radiosensitivity in normal members of the population (Weichselbaum et al., 1976) most work has been done on the inherited disorders. The underlying causes of the different responses to radiation are at present not understood, but it seems likely that more than a single factor is important. In ataxia telangiectasia, for example, particular tumor types are associated with radiation sensitivity in these patients. This suggests that particular cell types or differentiation states are more susceptible to the consequences of the possible repair deficiency in these patients.
KeywordsBasal Cell Carcinoma Ataxia Telangiectasia Irradiate Field Retinoblastoma Patient Induce Chromosome Aberration
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