Lipoxins pp 107-130 | Cite as

Actions of Lipoxin A4 and Related Compounds in Smooth Muscle Preparations and on the Microcirculation in Vivo

  • Sven-Erik Dahlén
  • Lilian Franzén
  • Johan Raud
  • Eva Wikström
  • Thure Björck
  • Hisao Matsuda
  • Pär Westlund
  • Tapio Puustinen
  • Jesper Haeggström
  • Bengt Samuelsson
  • Charles N. Serhan
  • Stephen E. Webber
  • Chris A. Veale
  • K. C. Nicolaou

Abstract

The present chapter summarizes our findings with lipoxins (LX) in spasmogenic assays and in the intact microvasculature of the hamster cheek pouch. The initial observations1,2 were made in experiments using lipoxins isolated from human leukocytes. With the aid of synthetic compounds3, it has been possible to further explore the pharmacodynamics and structure activity relationships for lipoxins in smooth muscle preparations.

Keywords

Contractile Activity Eicosatetraenoic Acid Hamster Cheek Pouch Human Bronchus Smooth Muscle Preparation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Sven-Erik Dahlén
    • 1
  • Lilian Franzén
    • 1
  • Johan Raud
    • 1
  • Eva Wikström
    • 1
  • Thure Björck
    • 1
  • Hisao Matsuda
    • 1
  • Pär Westlund
    • 2
  • Tapio Puustinen
    • 2
  • Jesper Haeggström
    • 2
  • Bengt Samuelsson
    • 2
  • Charles N. Serhan
    • 2
    • 3
  • Stephen E. Webber
    • 4
  • Chris A. Veale
    • 4
  • K. C. Nicolaou
    • 4
  1. 1.Department of Physiology Karolinska Institutetthe National Institute of Environmental MedicineStockholmSweden
  2. 2.Department of Physiological ChemistryKarolinska InstitutetStockholmSweden
  3. 3.Hematology DivisionBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA
  4. 4.Department of ChemistryUniversity of PennsylvaniaPhiladelphiaUSA

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