Kinins—II pp 29-37 | Cite as

Comparative Study on Distribution of Bombesin-, Neurotensin- and α-Endorphin-Like Immunoreactivities in Canine Tissues

  • N. Yanaihara
  • H. Sato
  • A. Inoue
  • N. Sakura
  • M. Sakagami
  • T. Mochizuki
  • H. Nakamura
  • C. Yanaihara
Part of the Advances in Experimental Medicine and Biology book series (AEMB)

Abstract

Bombesin and neurotensin, which have recently been found in both brain and intestine tissues, were originally isolated from frog skin (Anastasi et al., 1971) and from bovine hypothalamus (Carraway and Leeman, 1973 and 1975), respectively. Both the peptides have been reported to show a wide spectrum of actions in mammals. Neurotensin possesses pharmacological actions which are similar to those of the mammalian plasma kinins. Bombesin is also known to possess a variety of actions on isolated smooth muscle preparations and cardiovascular system (Nelchiorri, 1978). It has recently reported that bombesin and neurotensin show potent action on thermoregulation (Brown et al., 1977).

Keywords

Frog Skin Intermediate Lobe Pineal Body Peptide Chemistry Smooth Muscle Preparation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Anastasi, A., V. Erspamer and M. Bucci, 1971, Isolation and structure of bombesin and alytensin, two analogous active peptides from the skin of the European amphibians, Bombina and Alytes, Experientia 27, 166.Google Scholar
  2. Bloom, F., E. Battenberg, J. Rossier, N. Ling, J. Leppalusto, T.M. Vargo and R. Guillemin, 1977, Endorphins are localised in the intermediate and anterior lobes of the pituitary gland, not in the neurohypophysis, Life Sciences, 20, 43.PubMedCrossRefGoogle Scholar
  3. Bradburg, A.F., D.G. Smyth and C.R. Snell, 1975, Biosynthesis of ß-MSH and ACTH, in: Peptides: Chemistry, Structure and Biology, eds. R. Walter and J. Meienhofer ( Ann Arbor Sci. Inc., Michigan ) p. 609.Google Scholar
  4. Brown, M.R., J.R. Rivier and W.W. Vale, 1977, Bombesin: potent effects of thermoregulation in the rat, Science, 196, 998.PubMedCrossRefGoogle Scholar
  5. Carraway, R., and S.E. Leeman, 1973, The isolation of a new hypothalamic peptide, neurotensin, from bovine hypothalamic, J.Biol.Chem., 248, 6854.PubMedGoogle Scholar
  6. Carraway, R., and S.E. Leeman, 1975, The amino acid sequence of a hypothalamic peptide, neurotensin, J.Biol.Chem., 250, 1907.PubMedGoogle Scholar
  7. Kobayashi, R.M., M.R. Brown and W. Vale, 1977, Regional distribution of neurotensin and somatostatin in rat brain, Brain Research, 126, 584.PubMedCrossRefGoogle Scholar
  8. Ling, N., R. Burgus and R. Guilemin, 1976, Isolation, primary struc-ture and synthesis of a-endorphin and y-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomímatic activity, Proc.Natl.Acad.Sci., 73, 3942.PubMedCrossRefGoogle Scholar
  9. Melchiorri, P., 1978, Bombesin and bombesin-like peptides of amphibian skin, in: Gut Hormones, ed. S.R. Bloom ( Churchill Livingstone, Edinburgh ) p. 534.Google Scholar
  10. Orci, L., 0. Baetens, C. Rufener, M. Brown, W. Vale and R. Guillemin, 1976, Evidence for immunoreactive neurotensin in dog intestinal mucosa, Life Sciences, 19, 559.Google Scholar
  11. Polak, J.M., S. Hobbs, S.R. Bloom, E. Solcia and A.G.E. Pearse, 1976, Distribution of a bombesin-like peptide in human gastrointestinal tract, Lancet,l., 1109.Google Scholar
  12. Polak, J.M., S.N. Sullivan, S.R, Bloom, A.M.J. Buchan, P. Facer, M.R. Brown and A.G.E. Pearse, 1977, Specific localisation of neurotensin to the N cell in human intestine by radioímmunoassay and immunocytochemistry, Nature, 270, 183.PubMedCrossRefGoogle Scholar
  13. Rossier, J., T.M. Vargo, S. Minick, N. Ling, F.E. Bloom and R. Guillemin,1977, Regional dissociation of 8-endorphin and enkephalin contents in rat brain and pituitary, Proc.Natl.Acad.Sci.USA, 74, 5162.Google Scholar
  14. Sakura, N., and N. Yanaihara, 1978, Syntheses of some ß-LPH-related peptides, in: Peptide Chemistry 1977, ed. T. Shiba ( Protein Research Foundation Press, Osaka ) p. 183.Google Scholar
  15. Straus, E., and R.S. Yalow, 1978, Species specificity of cholecystokinin in gut and several mammalian species, Proc.Natl.Acad.Sci. USA, 75, 486.Google Scholar
  16. Uhl, G.R. and S.H. Snyder, 1976, Regional and subcellular distribution of brain neurotensin, Life Sciences, 19, 1827.PubMedCrossRefGoogle Scholar
  17. Yanaihara, C., H. Sato, M. Hirohashi, M. Sakagamí, K. Yamamoto, T. Hashimoto, N. Yanaihara, K. Abe and T. Kaneko, 1976, Substance P radioimmunoassay using Na-tyrosyl-substance P and demonstration of the presence of substance P-like immunoreactivities in human blood and porcine tissue extracts, Endocrinol.Japon., 23, 457.CrossRefGoogle Scholar
  18. Yanaíhara, C., A. Inoue, T. 14ochizukí, N. Sakura, H. Sato and N. Yanaihara, 1978, Synthesis of bombesin-related peptides and their use for bombesin-specific radioimmunoassay, in: Peptide Chemistry 1978, ed. N. Izumiya (Protein Research Foundation Press, Osaka) in press.Google Scholar
  19. Yoshida, H., T. Nakajima, K. Sakurai and Y. Fujita, 1974, Studies on high speed liquid chromatography on porous polymer and the separation of peptides. Isolation of biologically active peptides from the skin of Rana catesbeíana, in: Peptide Chemistry 1973, ed. H. Kotake(Protein Research Foundation Press, Osaka ) p. 115.Google Scholar

Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • N. Yanaihara
    • 1
  • H. Sato
    • 1
  • A. Inoue
    • 1
  • N. Sakura
    • 1
  • M. Sakagami
    • 1
  • T. Mochizuki
    • 1
  • H. Nakamura
    • 1
  • C. Yanaihara
    • 1
  1. 1.Laboratory of Bioorganic ChemistryShizuoka College of PharmacyShizuokaJapan 422

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