Kinins—II pp 375-391 | Cite as

How do Kinins Affect Vascular Tone?

  • Una S. Ryan
  • James W. Ryan
  • Cecil Whitaker
Part of the Advances in Experimental Medicine and Biology book series (AEMB)

Abstract

Because kinins affect vascular tone, it is assumed that kinins act directly on smooth muscle. However, a direct interaction.is difficult to conceive. Vessels containing smooth muscle are lined by a continuous endothelium with tight junctions. In addition, kinins act on endothelial cells to cause the release of prostaglandin-related substances; possibly through receptors. Furthermore, endothelial cells have a great capacity for hydrolyzing kinins to inactive products. Hence, even invoking active transport, less than 1% of kinins might be expected to reach the first layer of smooth muscle cells. However, kinins may not act directly on smooth muscle as endothelial cells and smooth muscle cells form. specialized cell contacts. Myoendothelial junctions occur, and we have shown, in pulmonary arterioles, that smooth muscle cells send large numbers of projections into the cytoplasm of the endothelial cells. In addition, smooth muscle cells attach directly to the abluminal surface of endothelial cells, as do pericytes. Thus, there is a morphologic basis by which kinins can affect tone of smooth muscle without acting directly on smooth muscle cells.

Keywords

Endothelial Cell Angiotensin Converting Enzyme Pulmonary Vascular Resistance Vascular Tone High Affinity Binding Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • Una S. Ryan
    • 1
  • James W. Ryan
    • 1
  • Cecil Whitaker
    • 1
  1. 1.Department of MedicineUniversity of Miami School of MedicineMiamiUSA

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