The Use of Monoclonal Antibodies in Studies of the Structural Proteins of Togaviruses and Flaviviruses
Since the initial reports of the isolation and characterization of monoclonal antibodies (MAb’s) specific for alphaviruses (Roehrig et al., 1980) and flaviviruses (Dittmar et al., 1980), the arbovirus community has experienced a virtual explosion in the research applications of MAb’s to the antigenic analysis of these important human and veterinary pathogens. This research, reviewed in the following pages, has revolutionized our understanding of both the molecular and the clinical immunology of togaviruses and flaviviruses.
KeywordsJapanese Encephalitis Virus Japanese Encephalitis Semliki Forest Virus Sindbis Virus Yellow Fever Virus
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