Phencyclidine (PCP)

  • Marc A. Schuckit
Part of the Critical Issues in Psychiatry book series (CIPS)

Abstract

In the intervening years between the editions of this text, the misuse of PCP has expanded. Phencyclidine has become one of the more widely misused drugs in the Western cultures (along with alcohol, tobacco, stimulants, and caffeine), being taken both deliberately as a drug of intoxication and inadvertently by individuals who believe that they are buying another substance.

Keywords

Clinical Psychiatry Toxic Reaction Research Monograph Organic Brain Syndrome Violent Outburst 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Jaffe, J. H. Drug addiction and drug abuse. In A. G. Gilman, L. S. Goodman, T. W. Rall, und F. Murad (Eds.), The Pharmacological Basis of Therapeutics ( 7th ed. ). New York: Macmillan, 1985, pp. 565–568.Google Scholar
  2. 2.
    Gelenberg, A. H. Psychopharmacology update. McLean Hospital Journal 2: 89–96, 1977.Google Scholar
  3. 3.
    Garey, R. E., Dual, G. C., Samuels, M. S., PCP abuse in New Orleans: A six-year study. American Journal of Drug and Alcohol Abuse 13:135–144, 1987.Google Scholar
  4. 4.
    Aniline, O., und Pitts, F. N. Incidental intoxication with PCP. Journal of Clinical Psychiatry 41: 393–394, 1980.Google Scholar
  5. 5.
    Woolverton, W. L., und Balster, R. L. Tolerance to the behavioral effects of phencyclidine: The importance of behavioral and pharmacological variables. Psychopharmacology 64: 19–24, 1979.PubMedCrossRefGoogle Scholar
  6. 6.
    Domino, E. F. Neurobiology of PCP: An update. In R. C. Petersen und R. C. Stillman (Eds.), PCP Abuse. Rockville, Maryland: NIDA Research Monograph 21: 210–217, 1978.Google Scholar
  7. 7.
    Montgomery, P. T., und Mueller, M. E. Treatment of PCP intoxication with verapamil. American Journal of Psychiatry 142: 882, 1985.PubMedGoogle Scholar
  8. 8.
    Giannini, A. J., Loiselle, R. J., Price, W. A., und Giannini, M. C. Chlorpromazine vs. meperidine in the treatment of phencyclidine psychosis. Journal of Clinical Psychiatry 46: 52–54, 1985.PubMedGoogle Scholar
  9. 9.
    Castellani, S., und Adams, P. M. Effects of dopaminergic and cholinergic agents on phencyclidine behaviors in rats. Neuropharmacology 20: 371–374, 1981.PubMedCrossRefGoogle Scholar
  10. 10.
    Grover, D., Yeragani, V. K., und Keshavan, M. S. Improvement of phencyclidine-associated psychosis with ECT. Journal of Clinical Psychiatry 47: 477–478, 1986.Google Scholar
  11. 11.
    Marwaha, J. Candidate mechanisms underlying phencyclidine-induced psychosis: An electrophysiological, behavioral, and biochemical study. Biological Psychiatry 17:155–162, 1982.Google Scholar
  12. 12.
    Khajawall, A. M. Characteristics of chronic phencyclidine abusers. American Journal of Drug and Alcohol Abuse 8: 301–310, 1981.PubMedCrossRefGoogle Scholar
  13. 13.
    Fauman, M. A., und Fauman, B. J. The psychiatric aspects of chronic PCP use. In R. C. Petersen und R. C. Stillman (Eds.), PCP Abuse. Rockville, Maryland: NIDA Research Monograph 21:183–200, 1978.Google Scholar
  14. 14.
    Cohen, S. (Ed.). Flashbacks. Drug Abuse and Alcoholism Newsletter 6:1–3, 1977.Google Scholar
  15. 15.
    McCarron, M. M., Schulze, B. W., Thompson, G. A., Acute phencyclidine intoxication: Clinical patterns, complications, and treatment. Annals of Emergency Medicine 10: 290–297, 1981.PubMedCrossRefGoogle Scholar
  16. 16.
    Brunet, B. L., Reiffenstein, R. J., Williams, T., und Wong, L. Toxicity of phencyclidine and ethanol combination. Alcohol and Drug Research 6: 341–349, 1986.Google Scholar
  17. 17.
    McCarron, M. M., Schlze, V. W., Thompson, D. M., und Winsauer, P. J. Effects of opioids and phencyclidine intoxication: Incidence of clinical findings in 1000 cases. Annals of Emergency Medicine 10: 347–242, 1981.Google Scholar
  18. 18.
    Fauman, M. A., und Fauman, B. J. Violence associated with PCP abuse. American Journal of Psychiatry 136:1584–1586, 1979.Google Scholar
  19. 19.
    Ragheb, M. Drug abuse among state hospital psychiatric inpatients with particular reference to PCP. Journal of Clinical Psychiatry 46: 339–340, 1985.PubMedGoogle Scholar
  20. 20.
    Davis, B. L. The PCP epidemic: A critical review. International Journal of the Addictions 17:1137-1155, 1982.Google Scholar
  21. 21.
    Yago, K. B., Pitts, F. N., Burgoyne, R. W., The urban epidemic of phencyclidine (PCP) use: Clinical and laboratory evidence from a public psychiatric hospital emergency service. Journal of Clinical Psychiatry 42:193–196, 1981.Google Scholar
  22. 22.
    Aniline, O., Allen, R. E., Pitts, F. N, The urban epidemic of phencyclidine use: Laboratory evidence from a public psychiatric hospital inpatient service. Biological Psychiatry 15: 813–817, 1980.PubMedGoogle Scholar
  23. 23.
    Smart, R. G., Goodstadt, M. S., Adlaf, E. M., Trends in the prevalence of alcohol and other drug use among Ontario students: 1977–1983. Canadian Journal of Public Health 76: 157–161, 1985.Google Scholar
  24. 24.
    Smart, R. G., Adlaf, E. M., und Goodstadt, M. S. Alcohol and other drug use among Ontario students: An update. Canadian Journal of Public Health 77: 57–58, 2986.Google Scholar
  25. 25.
    Fauman, M. A., und Fauman, B. J. Violence associated with phencyclidine abuse. American Journal of Psychiatry 136:1584–1586, 1979.Google Scholar
  26. 26.
    Cohen, S. (Ed.), PCP: New trends in treatment. Drug Abuse and Alcoholism Newsletter 5: 1–4, 1978.Google Scholar
  27. 27.
    Walker, S., Yesavage, J. A., und Tinklenberg, J. R. Acute phencyclidine (PCP) intoxication: Quantitative urine levels and clinical management. American Journal of Psychiatry 138:674–675, 1981.Google Scholar
  28. 28.
    Crosby, C. J., und Binet, E. F. Cerebrovascular complications in PCP intoxication. Journal of Pediatrics 94:316–318, 1979.Google Scholar
  29. 29.
    Johnson, K. M. Neurochemical pharmacology of PCP. In R. C. Petersen und R. C. Stillman (Eds.), PCP Abuse. Rockville, Maryland: NIDA Research Monograph 21: 44–52, 1978.Google Scholar
  30. 30.
    Giannini, A. J., Loiselle, R. H., DiMarzio, L. R., und Giannini, M. C. Augmentation of haloperidol by ascorbic acid in phencyclidine intoxication. American Journal of Psychiatry 144: 1207–1209, 1987.PubMedGoogle Scholar
  31. 31.
    Castellani, S., Giannini, J., und Adams, P. M. Physostigmine and haloperidol treatment of acute phencyclidine intoxication. American Journal of Psychiatry 139: 508–510, 1982.PubMedGoogle Scholar
  32. 32.
    Done, A. K., Aranow, R., und Miceli, J. N. Pharmacokinetics of PCP in overdosage and its treatment. In R. C. Petersen und R. C. Stillman (Eds.), PCP Abuse. Rockville, Maryland: NIDA Research Monograph 21: 210–217, 1978.Google Scholar
  33. 33.
    Berglant, J. L. Reserpine and phencyclidine-associated psychosis: Three case reports. Journal of Clinical Psychiatry 46: 542–544, 1985.Google Scholar
  34. 34.
    Yesavage, J. A., und Freman, A. M. Acute PCP intoxication. Journal of Clinical Psychiatry 39: 664-666, 1978.Google Scholar
  35. 35.
    Slavney, P. R., Rich, G. B., Pearlson, G. D., Phencyclidine abuse and symptomatic mania. Biological Psychiatry 12: 697–700, 1977.PubMedGoogle Scholar
  36. 36.
    Tennant, F. S., Rawson, R. A., und McCann, M. Withdrawal from chronic phencyclidine (PCP) dependence with desipramine. American Journal of Psychiatry 138: 845–847, 1981.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Marc A. Schuckit
    • 1
  1. 1.San Diego School of Medicine, Veterans Administration HospitalUniversity of CaliforniaSan DiegoUSA

Personalised recommendations