H-2 Antigens pp 681-689 | Cite as

The H-2 Complex and the Hormonal Factors in Mammary Tumorigenesis in Mice

  • G. Röpcke
  • M. Sluyser
  • P. Demant
Part of the NATO ASI Series book series (NSSA, volume 144)

Abstract

Induction of mammary tumors by hormonal stimulation from heterotopic hypophyseal isografts has been studied in H-2 congenic mouse strains free of infectious mammary tumor virus. Significant differences in tumor incidence have been observed, indicating that H-2-linked genes influence the tumorigenesis in hormonally stimulated mammary glands. In addition, significant differences between the H-2 congenic strains were found in estrogen receptor levels measured in the hypophyseal isografts. These differences do not appear to correlate in any obvious way with the induction of mammary tumors. Our data indicate that the MHC or MHC-linked genes influence one or more steps related to hormonal regulation of the mammary gland.

Keywords

Mammary Gland Hormonal Stimulation Mouse Mammary Tumor Virus Congenic Strain Mammary Tumorigenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ashley, R.L., Cardiff, R.D., and Fanning, T.G.: Reevaluation of the effect of mouse mammary tumor virus infection on the BALB/c mouse hyperplastic outgrowth. J. Natl. Cancer Inst. 65 977-986, 1980Google Scholar
  2. Bailey, D.W., and Hoste, J.: A gene governing the female immune response to the male antigen in mice. Transplantation 11 404 - 407, 1971Google Scholar
  3. Ballard, P.L.: Hormones and receptors in developing lung. Progr. Clin. Biol. Res. 140 103-117, 1983Google Scholar
  4. Boot, L.M., Kwa, H.G., and Röpcke, G.: Hormonal induction of the mouse mammary tumors. In J. Hilgers and M. Sluyser (eds.): Mammary tumors in the mouse pp. 117 - 200, Elsevier/North-Holland Biomedical Press, Amsterdam, 1981Google Scholar
  5. Carlsson, K.S., Smith, B.T., and Post, M.: Insulin acts on the fibroblast to inhibit glucocorticoid stimulation of lung maturation. J. Appl. Physiol. 57 1577-1579, 1984Google Scholar
  6. Demant, P.: Corticosteroid-induced cleft palate: Cis interaction of MHC genes and hybrid resistance. Immunogenetics 22 183-188, 1985Google Scholar
  7. Dunn, T.B.: Morphology of mammary tumors in mice. In F. Homburger (ed.): Physiopathology of Cancer 2nd ed., pp. 38-814, Hoeber, New York, 1959Google Scholar
  8. Dux, A.: Multiple genetic factors in the MHC and predominant role of D-end in the resistance against C3H-MTV-induced mammary tumors. Transpl. Proc. 15 2101-2103, 1983Google Scholar
  9. Dux, A., and Demant, P.: The influence of the MHC on resistance against C3H-MTV induced mammary tumors is predominantly systemic rather than local. Int. J. Cancer in pressGoogle Scholar
  10. Hitchcock, K.R.: Lung development and the pulmonary surfactant system: hormonal influences. Anat. Rec. 198 13-3-4, 1980Google Scholar
  11. Klein, J., Figueroa, R., and David, C.S.: H-2 haplotypes, genes and antigens: Second listing. II. The H-2 complex. Immunogenetics 17 553-596, 1983Google Scholar
  12. Kwa, H.G., Verstraeten, A.A., and Scheijde-Bakker, M.G.M.: Isolation of prolactin from the granular fraction of pituitary tumour transplants: Improved method for the isolation of mouse and rat prolactin for radioimmunoassay. Eur. J. Cancer 8 33-38, 1972Google Scholar
  13. Long, C.A., Vaidya, A.B., and Dumaswala, U.J.: Influence of the major histocompatibility complex on susceptibility to MuMTV. Abstract 12th meeting on mammary cancer in experimental animals and man, Maastricht, 1980Google Scholar
  14. Mantel, N.: Evaluation of survival data and two new rank order statistics arising and its consideration. Cancer Chemother. Rep. 50 163-170, 1966Google Scholar
  15. Mühlbock, 0., and Dux, A.: Histocompatibility genes and susceptibility to mammary tumor virus (MTV) in mice. Transpl. Proc. 3 1247-1250, 1971Google Scholar
  16. Mühlbock, 0., and Dux, A.: Histocompatibility genes and mammary cancer. In J. Hilgers and M. Sluyser (eds.): Mammary tumors in the mouse pp. 5145-572, Elsevier/North-Holland Biomedical Press, Amsterdam, 1981Google Scholar
  17. Nagasawa, H., Yanai, R., Taniguchi, H., Tokuzen, R., and Nakahara, W.: Two way selection of a stock of Swiss albino mice for mammary tumorigenesis: Establishment of two new strains (SHN and SLN). J. Natl. Cancer Inst. 57 1425-429, 1976Google Scholar
  18. Oomen, L.C.J.M., Demant, P., Hart, A.A.M., and Emmelot, P.: Multiple genes in the H-2 complex affect differently the number and growth rate of transplacentally induced lung tumors in mice. Int. J. Cancer 31: 447-454, 1983Google Scholar
  19. Palumbo, D.A., and Vladutiu, A.O.: Estrogen receptor in uteri of mice of different H-2 genotypes. Experientia 35 1103-11014, 1979Google Scholar
  20. Röpcke, G.: Interaction of hypophyseal isografts and ovarian hormones in mammary tumour development in mice. Thesis University of Amsterdam, 1975Google Scholar
  21. Sluyser, M., Boot, L.M., and Röpcke, G.: High estrogen and low progestin receptor levels in outgrowths of hypophyseal isografts. Cancer Res. 38: 2859 - 2860, 1978Google Scholar
  22. Smith, B.T., and Sabry, K.: Glucocorticoid-thyroid synergism in lung maturation: A mechanism involving epithelial-mesenchyneal interaction. Proc. Natl. Acad. Sci. USA 80 1951-1954, 1983Google Scholar
  23. Zijlstra, M., Vasmel, W.L.E., Radaskiewicz, T., Matthews, E., and Melief, C.J.M.: The H-2 complex regulates both the susceptibility to murine viral lymphomagenesis and the phenotype of the virus-induced lymphomas. J. of Immunogenetics 13 69-76, 1986Google Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • G. Röpcke
    • 1
  • M. Sluyser
    • 1
  • P. Demant
    • 1
  1. 1.Departments of Molecular Genetics and Tumor Biology The Netherlands Cancer InstitutePlesmanlaan 121AmsterdamThe Netherlands

Personalised recommendations