H-2 Antigens pp 531-540 | Cite as

Do Class II Major Histocompatibility Molecules Function as Signal Transducers during B Lymphocyte Activation?

  • M. K. Newell
  • L. B. Justement
  • K. Lehman
  • K. Caldwell
  • D. M. F. Cooper
  • J. H. Freed
  • J. C. Cambier
Chapter
Part of the NATO ASI Series book series (NSSA, volume 144)

Abstract

The studies described here address the hypothesis that class II molecules (Ia) serve not only as restriction elements for cognate T cell:B cell interaction, but also as signal transducers involved in B cell activation. We have tested this hypothesis by studying modulation of B cell physiology by anti-Ia antibodies. Specifically, we have assessed the ability of these antibodies to induce “second” messenger generation and to modulate cell proliferative and differentiative responses to LPS and anti IgM antibodies.

Keywords

Adenylate Cyclase None None Cellular cAMP cAMP Generation Cell Surface Signal Transduction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • M. K. Newell
    • 1
    • 2
  • L. B. Justement
    • 1
  • K. Lehman
    • 1
  • K. Caldwell
    • 2
  • D. M. F. Cooper
    • 2
  • J. H. Freed
    • 1
    • 2
  • J. C. Cambier
    • 1
    • 2
  1. 1.National Jewish Center for Immunology and Respiratory MedicineUSA
  2. 2.University of Colorado Health Sciences CenterDenverUSA

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