H-2 Antigens pp 201-208 | Cite as

Regulatory Elements in the Promoter of the H-2Dd Class I Gene

  • Bette Korber
  • Leroy Hood
  • Iwona Stroynowski
Part of the NATO ASI Series book series (NSSA, volume 144)

Abstract

Murine class I antigen expression undergoes modulation during development and adult life. Early embryonic cells do not transcribe detectable amounts of class I and β2 microglobulin mRNA and express little, if any, H-2 antigens (1,2). In contrast, adult cells express class I mRNA constitutively and ubiquitously but the relative basal level of class I antigen expression varies on different cells and tissues (reviewed in 3). The quantity of various class I antigens expressed undergoes additional changes upon exposure to agents such as type I and type Ilinterferons and tumor necrosis factor (4–6). Since quantitative variation in class I protein expression can influence the acquisition of tolerance, MHC restriction, and the efficiency of cell-mediated immune responses we were interested in identifying and characterizing the DNA elements and trans-acting factors which are important for the regulation of class I gene expression. This information may be eventually applied for therapeutic purposes to modulate class I protein levels and to affect the immune response in vivo.

Keywords

Nuclear Extract TATA Motif Cell Nuclear Extract Thymidine Kinase Promoter CCAAT Motif 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Bette Korber
    • 1
  • Leroy Hood
    • 1
  • Iwona Stroynowski
    • 1
  1. 1.Division of BiologyCalifornia Institute of TechnologyPasadenaUSA

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