The Importance of Energy Intake for Preventing the Accumulation of Guanidino Compounds in Patients with Chronic Renal Failure
It is now recognized that methylguanidine (MG) and guanidinosuccinic acid (GSA) are the prototypes of low molecular weight uremic toxins1,2. There remain, however, many problems concerning the origin of these substances. This study is designed to evaluate the effect of dietary energy intake in preventing the accumulation of MG and GSA. We report that in the presence of a high energy intake the serum levels of MG, GSA, and urea nitrogen diminish and the nutritional status improves.
KeywordsEnergy Intake Chronic Renal Failure Succinic Acid Urea Synthesis High Energy Intake
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- 3.G. Grodstein, M. J. Blumenkrantz and J. D. Kopple,Nutritional and metabolic response to catabolic stress in uremia, Am. J. Clin. Nutr., 33: 1411 (1980).Google Scholar
- 5.A. Ando, Y. Orita, K. Nakata, Y. Tsubakihara, Y. Takamitsu, N. Ueda, M. Yanase and H. Abe, Effect of low protein diet and surplus of essential amino acids on the serum concentration and the urinary excretion of methylguanidine and guanidino succinic acid in chronic renal failure, Nephron., 24: 161 (1979).Google Scholar