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The Effect of Chromium on Glucose Tolerance in Turner’s Syndrome

  • G. Saner
  • O. Neyzi
  • H. Gunoz
  • N. Saka
  • V. Yuzbasiyan
  • S. Cigdem
Chapter

Abstract

Although a high frequency of diabetes mellitus in patients with Turner’s syndrome and also in their relatives has been reported by several investigators (Forbes and Engel, 1965; Menzinger et al., 1966; Lindsten et al., 1967; Nielsen et al., 1969; Polychronakos et al., 1980) the etiology and pathogenesis of abnormal, carbohydrate metabolism in these patients has not been clarified. Both resistance to and inadequate or delayed release of insulin have been demonstrated in Turner’s syndrome (Lindsten et al., 1967; Nielsen et al., 1969; Rasio et al., 1976). It is known that chromium (III) has a role in carbohydrate metabolism by increasing the effectiveness of insulin, thereby facilitating the transport of glucose into the cell (Mertz, 1969).

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References

  1. Forbes, A.P. and Engel, E., 1965, The high incidence of diabetes mellitus in 41 patients with gonadal dysgenesis and their close relatives, Medicine 44: 135.Google Scholar
  2. Hales, C.N. and Randle, P.J., 1963, Immunoassay of insulin with insulin antibody precipitate, Biochem. J. 88: 137.Google Scholar
  3. Lindsten, J., Cerasi, E., Luft, R. and Hultquist, G., 1967, The occurrence of abnormal insulin and growth hormone (HGH) responses to sustained hyperglycaemia in a disease with sex chromosome aberrations (Turner’s syndrome), Acta Endocrinol. 56: 107.Google Scholar
  4. Marks, V., 1959, An improved glucose-oxidase method for determining blood, CSF and urine glucose levels, Clin. Chim. Acta 4: 395Google Scholar
  5. Menzinger, G., Fallucca, F. and Andreani, D., 1966, Gonadal dysgenesis and diabetes, Lancet 1: 1269.Google Scholar
  6. Mertz, W., 1969, Chromium occurrence and function in biological systems, Physiol. Rev., 49: 163.PubMedGoogle Scholar
  7. Nielsen, J., Johansen, K. and Yde, Y., 1969, The frequency of diabetes mellitus in patients with Turner’s syndrome and pure gonadal dysgenesis, Acta Endocrinol. 62: 251.Google Scholar
  8. Polychronakos, C., Letarte, J., Collu, R. and Ducharme, J.R., 1980, Carbohydrate intolerance in children and adolescents with Turner syndrome, J. Pediatr. 96: 1009.PubMedCrossRefGoogle Scholar
  9. Rasio, E., Antaki, A. and Van Campenhout, S., 1976, Diabetes mellitus in gonadal dysgenesis: studies of insulin and growth hormone secretion, Eur. J. Clin. Invest. 6: 59.PubMedCrossRefGoogle Scholar
  10. Saner, G., 1980, Current Topics in Nutrition and Disease, Vol. 2., Chromium in nutrition and disease, Alan R. Liss, Inc., New York.Google Scholar
  11. Vecchio, T.J., Oster, H.L. and Smith, D.L., 1965, Oral sodium, tol- butamide and glucose tolerance tests, Arch. Intern. Med. 115: 161.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • G. Saner
    • 1
  • O. Neyzi
    • 1
  • H. Gunoz
    • 1
  • N. Saka
    • 1
  • V. Yuzbasiyan
    • 1
  • S. Cigdem
    • 1
  1. 1.Department of PediatricsIstanbul Faculty of Medicine CapaIstanbulTurkey

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