The Effect of Chromium on Glucose Tolerance in Turner’s Syndrome
Although a high frequency of diabetes mellitus in patients with Turner’s syndrome and also in their relatives has been reported by several investigators (Forbes and Engel, 1965; Menzinger et al., 1966; Lindsten et al., 1967; Nielsen et al., 1969; Polychronakos et al., 1980) the etiology and pathogenesis of abnormal, carbohydrate metabolism in these patients has not been clarified. Both resistance to and inadequate or delayed release of insulin have been demonstrated in Turner’s syndrome (Lindsten et al., 1967; Nielsen et al., 1969; Rasio et al., 1976). It is known that chromium (III) has a role in carbohydrate metabolism by increasing the effectiveness of insulin, thereby facilitating the transport of glucose into the cell (Mertz, 1969).
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