Skeletal Maturation in the Early Human Fetus
In the study of problems of disordered growth, the concept of skeletal maturity as an index of biological development separate from chronological age has been of great value. The original “atlas” concept applied to an anatomical area of the skeleton, introduced by Todd and refined by Greulich and Pyle has been greatly extended by the “bone-specific” approach suggested first by Acheson (1954, 1957). The simple ordinal method of scoring bone stages gave no weight to the relative value of different centres of ossification. The concept of using weighted scores rather than simple ordinal ranking was perfected by Tanner and coworkers, especially in their TW2 system (1975). In this the numerical scores were weighted so as not to give undue weight to any particular bone or series of bones (e.g. digital ray) in the assessment, but the problem of assigning weightings to each individual stage of each bone is a mathematically monumental task, although it would be biologically preferable A stage which is attained and passed in a short period of time is of more “value” than one which exists for a lengthy period.
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- Acheson, R.M., 1957, The Oxford method of assessing skeletal maturity, Clin. Orthopaed., 10: 19–39.Google Scholar
- Birkbeck, J.A., 1976, Metrical growth and skeletal development of the human fetus, in: Roberts, D.F. and Thomson, A.M. (eds),The Biology of Human Fetal Growth. Symp. Soc. Study Hum. Biol., 15: 39–68.Google Scholar
- Hodges, P.C., 1953, Ossification in fetal pig: radiography study. Anat. Rec., 116: 315–326.Google Scholar
- O’Rahilly, R. and Meyer, D.B., 1956, Roentgenographic investigations of the human skeleton during early fetal life. Am. J. Roentgenol., 76: 455–468.Google Scholar
- Pryor, J.W., 1923, Differences in the time of development of centres of ossification in the male and female skeleton, Anat. Rec., 25: 257–273Google Scholar
- Tanner, J.M., Whitehouse, R.H., Marshall, W.A., Healy, M.J.R. and Goldstein, H., 1975, Assessment of skeletal maturity and prediction of adult height (TW2-method). London: Academic Press.Google Scholar