Renin and Precursors: Purification, Characterization, and Studies on Active Site

  • Tadashi Inagami
  • Kazuo Murakami
  • Kunio Misono
  • Robert J. Workman
  • Stanley Cohen
  • Yasunobu Suketa
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)

Abstract

Renin is an enzyme elaborated in juxta glomerular cells of the kidney and released into the blood stream by various stimuli. Although it is an endopeptidase, its function is strictly limited to the formation of angiotensin I from angiotensinogen by the cleavage of a unique leucyl-leucine peptide bond in this substrate molecule (Fig.l). Angiotensin I is converted into the octapeptide angiotensin II by a carboxydipeptidase, known as converting enzyme, and thenceforth to the heptapeptide angiotensin III by an aminopeptidase. Not only is angiotensin II the most potent pressor substance known, but both angiotensin II and III also stimulate the adrenal cortex to release the mineral corticoid aldosterone. Thus, renin triggers a chain of events aimed at elevating the blood pressure. Because of its strategically important position in the renin-angiosin-aldosterone system, the activity of renin in the circulation is tightly regulated by intricate multiple feedback control mechanisms. Excellent reviews on the control of renin release have been published recently (1–4).

Keywords

Acidic Protease Porcine Kidney Human Renin Cupric Acetate Renin Substrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1977

Authors and Affiliations

  • Tadashi Inagami
    • 1
  • Kazuo Murakami
    • 1
  • Kunio Misono
    • 1
  • Robert J. Workman
    • 1
  • Stanley Cohen
    • 1
  • Yasunobu Suketa
    • 1
  1. 1.Departments of Biochemistry and MedicineVanderbilt University School of MedicineNashvilleUSA

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