Evidence for the Role of Receptor Immobilization in Desensitization Subsequent to Hormonal Stimulation

  • David A. Jans
Part of the Molecular Biology Intelligence Unit book series (MBIU)

Abstract

We saw in the previous chapter that a body of indirect and direct experimental evidence supports the notion that receptor lateral mobility plays an integral role at the level of the membrane in transducing the stimulatory signal represented by hormone binding to receptor. This chapter intends to discuss the evidence for the assertion that if receptor lateral movement is important in hormonal stimulation, as it appears to be, arrestation of receptor movement must be central to the abrogation of the stimulatory signal subsequent to hormonal addition, as part of the cellular downregulatory apparatus.1,2 Particularly in the case of GTP-binding protein activating receptors where only mobile receptors appear to participate in signal transduction,1–5 it seems reasonable to suggest that desensitization of response subsequent to hormone addition involves the abrogation of receptor movement as an initial step. The evidence for this will be examined in some detail below, the conclusion being that agonistic stimulation triggers receptor immobilization prior to internalization. Receptor immobilization does not appear to exclusively play a role in downregulation of response subsequent to stimulation, however, but is also central to eliciting the stimulatory signal in several receptor systems, including those of tyrosine kinase receptors (as already mentioned in chapter 4) and receptors mediating cell-cell interaction or cell adhesion to the substratum, and these will be dealt with in chapter 7.

Keywords

Luteinizing Hormone Stimulatory Signal Renal Epithelial Cell Receptor Internalization Mobile Fraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© R.G. Landes Company 1997

Authors and Affiliations

  • David A. Jans
    • 1
  1. 1.John Curtin School of Medical ResearchAustralian National UniversityCanberraAustralia

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