Benzil, a Selective Inducer and a Potent in Vitro Activator of Microsomal Epoxide Hydrolase

  • Janeric Seidegård
  • Joseph W. Depierre
Part of the Advances in Experimental Medicine and Biology book series (AEMB)

Abstract

It is now well known that many chemical carcinogens, including the polycyclic hydrocarbons, must be metabolized to reactive intermediates before they can exert their biological effectsl. It is believed that both the carcinogenicity and mutagenicity of polycyclic hydrocarbons results from the covalent binding of such intermediates to protein, RNA, and/or DNA. In the case of benzo(a)pyrene the diol epoxide 7,8-dihydro-7,8dihydroxybenzo(a)pyrene-9,10-epoxide may well be the ultimate carcinogen.

Keywords

Epoxide Hydrolase Styrene Oxide Polycyclic Hydrocarbon Selective Inducer Microsomal Epoxide Hydrolase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Janeric Seidegård
    • 1
  • Joseph W. Depierre
    • 1
  1. 1.Department of Biochemistry, Arrhenius LaboratoryUniversity of StockholmStockholmSweden

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