Roles of Udp-Glucuronosyltransferase in the Inactivation of Benzo(a)Pyrene

  • K. W. Bock
  • B. S. Bock-Hennig
  • W. Lilienblum
  • H. Pfeil
  • R. F. Volp
Part of the Advances in Experimental Medicine and Biology book series (AEMB)

Abstract

It has become increasingly clear that the accumulation of reactive intermediates in cells depends upon a delicate balance between activating and detoxifying enzymes and upon numerous other pharmacokinetic factors. The importance of conjugating enzymes such as UDP-gIucuronosyltransferase (GT), which uses nucleophilic substrates instead of reactive electrophiles, is only recently beginning to be recognized in toxicological studies. It has become obvious that nucleophilic intermediate metabolites of aromatic hydrocarbons are often further metabolized to ultimate carcinogens (Sims et al., 1974; Levin et al., 1978). Moreover, glucuronides may be stable transport forms of toxic intermediates which may be reactivated at a site distant from their formation (Kadlubar et al., 1977; Kinoshita and Gelboin, 1978; Mulder et al., 1978).

Keywords

Liver Microsome Enzyme Form Ames Test Apparent Homogeneity Revertant Coloni 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • K. W. Bock
    • 1
  • B. S. Bock-Hennig
    • 1
  • W. Lilienblum
    • 1
  • H. Pfeil
    • 1
  • R. F. Volp
    • 1
  1. 1.Dept. of Pharmacology and ToxicologyUniversity of GöttingenGöttingenWest Germany

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