The Metabolic Activation of Some Polycyclic Hydrocarbons: The Role of Dihydrodiols and Diol-Epoxides

  • Peter Sims
Part of the Advances in Experimental Medicine and Biology book series (AEMB)

Abstract

It seems likely that events leading to the induction of cancer by polycyclic aromatic hydrocarbons involve a number of steps. However, the primary, initiating event appears to require the conversion of the carcinogens by metabolism into electrophiles that react with nucleophilic centres, such as those in nucleic acids, within the cells. Over recent years much effort has gone into the identification of these electrophiles and it now appears probable that they are vicinal diol-epoxides that arise from the hydrocarbons by threestep metabolic processes.

Keywords

Polycyclic Aromatic Hydrocarbon Metabolic Activation Chinese Hamster Ovary Cell Mouse Skin Chromatographic Property 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Peter Sims
    • 1
  1. 1.Chester Beatty Research InstituteInstitute of Cancer Research:Royal Cancer HospitalLondonUK

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