Reactive Metabolites as Key Intermediates in Pharmacologic and Toxicologic Responses: Examples from Chemical Carcinogenesis

  • Elizabeth C. Miller
  • James A. Miller
Part of the Advances in Experimental Medicine and Biology book series (AEMB)

Abstract

Five years have elapsed since the 1975 international conference on “Active Intermediates: Formation, Toxicity, and Inactivation” at the University of Turku, Turku, Finland. That conference and the volume that contained the record of its proceedings (Jollow et al., 1977) were landmarks in the field. Thus, that meeting was the first comprehensive international conference on the metabolic activation, reactivity, and conjugation of the wide range of biologically active xenobiotic molecules and on some of the biological consequences of the reactions of strong electrophilic reactants with cellular molecules. The international conference that we are opening today should provide us with an important up-dating of those data and concepts. It is a pleasure to have at this meeting many of those who participated in the Turku conference, as well as many other scientists contributing to this field.

Keywords

Chemical Carcinogen Reactive Metabolite Pharmacologic Response Carcinogenic Activity Chemical Carcinogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Elizabeth C. Miller
    • 1
  • James A. Miller
    • 1
  1. 1.McArdle Laboratory for Cancer ResearchUniversity of WisconsinMadisonUSA

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