Abstract

The occurrence of a species-specific bile acid in pig bile [Haslewood (1); Haslewood and Sjövall (2)] and of two such acids in rat bile [Bergstrom and Sjövall (3); Hsia et al. (4); Matschiner et al. (5)] was observed almost simultaneously. After their isolation and characterization, these acids were found to be isomeric 3α,6,7-trihydroxy-5β-cholanic acids. The acid from pig bile was named hyocholic acid [Haslewood (6); Ziegler (7)], and the two acids from rat bile were named α- and β-muricholic acids [Hsia et al. (8)]. The fourth isomer of these glycols was identified as a metabolite of hyodeoxycholic acid (3α,6α-dihydroxy-5β-cholanic acid) in the rat [Matschiner et al. (9, 10)], and was named ω-muricholic acid [Hsia et al. (8)]. The vicinal glycol structures in ring B of these acids are unique features, but even more unique are their species-specific characteristics which are particularly demonstrated in the metabolic pathways that lead to their formation.

Keywords

Bile Acid Cholic Acid Chenodeoxycholic Acid Raney Nickel Silver Acetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1971

Authors and Affiliations

  • S. L. Hsia
    • 1
  1. 1.University of Miami School of MedicineMiamiUSA

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